Developmental Biology and Gene Regulation

This study identifies Upd2 as a fat body-derived cytokine that directs JAK/STAT signaling in Drosophila tracheal progenitors to maintain disciplined migration.

This study induces homeotic transformations in salamander branchial regions using RA signaling inhibition, revealing ectopic gills and skeletal elements similar to fossil stem amphibians.

The paper quantifies positional information in the vertebrate neural tube using information theory and shows that signaling dynamics enhance positional precision.

This study investigates how Dscam1 proteins evolved strict homophilic specificity through evolutionary intermediates that allowed promiscuous interactions.

This study shows EFL-3 represses LIT-1/NLK to modulate Wnt signaling during asymmetric epidermal cell division in C. elegans.

This study investigates how the lens placode modulates extracellular matrix formation during early eye development in chicken and mouse models, showing a role for BMP signaling and Timp2 in ECM remodeling.

The paper identifies pseudogenisation of Nkx3.2 in monotremes and links it to unique gastric anatomy and physiology, suggesting gene loss influences phenotypic evolution.

The paper identifies four genes upregulated in the chick Organizer stem zone during axial elongation, defining its molecular identity.

This study identifies evolutionary modifications of the GoLoco motif in the AGS protein that facilitate micromere formation in sea urchin embryos by regulating asymmetric cell division.

The paper shows that enhanced Sonic Hedgehog signaling in cavefish modifies left-right organizer function, leading to reversed heart asymmetry.

This study shows SoxB1 factors are essential for NPB formation and maintenance, and identifies Pou5f3 as a partner in regulating NPB gene expression.

The paper describes the morphogenesis of the male tail tip in C. elegans, identifying a unique substage where one cell remains separate while others fuse to form a syncytium.

The paper identifies mechanical cues influencing epiblast cell fate in chicken embryos through single-cell RNA sequencing and lineage tracing.

The paper uses single-cell RNA-sequencing to study fibroblast diversity and developmental trajectories in chicken limb connective tissue, showing a shift from positional signaling to lineage diversification.

This study creates a single-cell transcriptomic atlas of pig gastrulation, revealing conserved and divergent gene programs and fate dynamics across species.

This study identifies Dzip1 as a novel germ plasm component in Xenopus and zebrafish that interacts with Dazl to regulate primordial germ cell development.

The paper identifies and characterizes intermediate states during neural crest cell epithelial to mesenchymal transition and delamination using single-cell RNA sequencing.

The paper identifies a single transcription factor isoform, broad-z4, as a terminal selector that controls neuronal identity in Drosophila by switching the identity of two visual projection neurons.

The paper examines transcriptional similarities between two neural lineages during ascidian embryogenesis and finds they cluster together despite limited shared transcriptional control.

The paper shows that Wnt signaling within the visceral endoderm restricts AVE differentiation, independent of BMP gradients, using mouse stem cell aggregates.

This study shows that CDK1 phosphorylates PAR-3 in asymmetrically dividing cells, affecting polarity and fate determination in Drosophila neuroblasts and sensory organ precursors.

The paper introduces Red2Flpe-SCON, a multicolor system for generating mosaic conditional knockout mice, and uses it to show Sox2 is not essential for stem cell maintenance but for proliferation and differentiation.

This paper introduces an optogenetic system to control morphogen production and study patterning dynamics in vitro, revealing how Shh concentration and duration affect neural progenitor domain formation.

The paper identifies 22 transcriptional regulators with distinct expression patterns in zebrafish spinal cord, suggesting potential roles in spinal cord development.

The paper shows that Nodal coordinates morphogenesis in annual killifish by enabling cell migration, while Huluwa-mediated prepatterning is not required.

The paper characterizes the transcriptional dynamics of the mouse Anterior Visceral Enderm (AVE) during migration and identifies Ephrin- and Semaphorin-signalling as critical for its movement.

This study develops a mathematical model to simulate the emergence of complexity in multicellular systems through cell division and lateral inhibition, using C. elegans as an example.

The paper studies how coordination between endoderm progression and gastruloid elongation influences endodermal morphotype choice, identifying key drivers and interventions to reduce variability.

This study shows that N-Cadherin-mediated cell rearrangements guide Drosophila embryonic macrophage migration and positioning.