Advanced MRI Techniques and Applications

Mapping Whole-Brain Auditory Activation with 3T Multi-Echo fMRI at the Group and Individual-Subject Level

This paper applies multi-echo fMRI and precision mapping to identify auditory activation patterns at both group and individual levels.

Temporally resolved glutamate and GABA responses measured in human medial frontal cortex during working memory encoding and recall

The paper measures glutamate and GABA dynamics in human medial frontal cortex during working memory encoding and recall using fMRS, finding distinct temporal patterns and differential roles for glutamate and GABA.

Voxel-accurate MRI-microscopy correlation enables AI-powered prediction of brain disease states

BRIDGE correlates MRI with cellular data to predict brain disease states using deep learning and high-resolution microscopy.

Ultra-High Field 31P functional Magnetic Resonance Spectroscopy Reveals NAD+ Dynamics in Brain Energy Metabolism during Visual Stimulation.

This study uses 7T 31P fMRS to show NAD+ decreases during visual stimulation in the human occipital lobe, with no change in other metabolites.

Microvascular network organization and hemodynamic perfusion protect the brain against hypoxia

The paper uses simulations to show brain microvascular networks provide oxygen supply resilience against hypoxia by maintaining oxygen tension through convective transport and capillary flow patterns.

Delineating In-Vivo T1-Weighted Intensity Profiles Within the Human Insula Cortex Using 7-Tesla MRI

This paper uses 7-Tesla MRI to identify distinct T1-weighted intensity profiles within the human insula cortex, revealing compartment-specific signal variations and highlighting atlas-dependent parcellation.

Concurrent multimodal imaging demonstrates that EEG-based excitation/inhibition balance reflects glutamate and GABA concentrations

The paper validates EEG-based E/I ratio algorithms against MRS-derived glutamate/GABA ratios, finding strong between-subject associations but weak within-subject ones.

p-Brain: An Automated MRI Pipeline for Cerebral Perfusion, Microvasculature, and Blood-Brain Barrier Permeability Estimation

p-Brain automates DCE-MRI analysis to estimate cerebral perfusion, microvasculature, and blood-brain barrier parameters with high agreement to reference methods.

Unsupervised anomaly detection for tumor delineation in a preclinical model of glioblastoma using CEST MRI

This paper develops an unsupervised anomaly detection method using CEST MRI to improve glioblastoma delineation in rats, achieving better performance than baseline models.

Longitudinal Resting-State fMRI of Awake Mice During Habituation: Stress, Head Motion, and Functional Connectivity

This study measures stress and head motion in mice during fMRI habituation and finds that CORT levels decrease with habituation outside the MRI but remain elevated during in-scanner habituation, while motion and connectivity remain stable.

Neuronal-Activity-Related Sodium (NARS) fMRI Reveals Millisecond Neuronal Dynamics Beyond Hemodynamic Readouts

This paper introduces NARS-fMRI, a method that detects millisecond neuronal activity via 23Na signal changes, showing it correlates with BOLD and glutamate transients in rodent somatosensory cortex.

Alteration of Water Exchange Rates Following Focused Ultrasound-Mediated BBB Opening in the Dorsal Striatum of Non-Human Primates: A Diffusion-Prepared pCASL Study

This study uses DP-pCASL to measure BBB water exchange rates before and after FUS-mediated BBB opening in non-human primates, finding localized decreases and global increases in Kw.

Susceptibility-matched padding improves the quality of cervical and lumbar spinal fMRI

This study evaluates susceptibility-matched padding's impact on spinal fMRI quality, finding improved B0 field homogeneity and functional image metrics in cervical and lumbar spinal cord scans.

Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke

This study shows that multi-echo fMRI techniques improve cerebrovascular reactivity estimates in stroke patients by reducing noise and negative values.

Accessible and reproducible mesoscale fMRI at 5.0 T: A Pulseq-based open framework for human laminar mapping

This paper develops an open-source framework for mesoscale fMRI at 5.0 T, demonstrating reliable laminar activation patterns comparable to 7.0 T systems.

Band-selective IR PRESS for brain tumor spectroscopy allows robust detection of lactate

This paper introduces SPIR-PRESS, a magnetic resonance spectroscopy method that improves lactate detection in brain tumors by reducing lipid interference, showing increased sensitivity and broader metabolite profiling.

High resolution and quantitative imaging of the postmortem brain

This study quantifies MRI parameters in fixed postmortem brains to assess variability and introduces a 3D method for high-resolution mapping of water content and relaxation times.

Simultaneous Real-time Imaging of Neurofluid and Neurovascular Dynamics Using Ultrafast Flow-weighted Echo-Planar Imaging

This paper introduces SURF-EPI, a real-time imaging technique that simultaneously captures CSF and neurovascular flow dynamics with high temporal resolution and without cardiac gating.

Whole-brain meso-vein imaging in living humans using fast 7 T MRI

This paper introduces a fast whole-brain MRI protocol for mesoscopic venous imaging in humans, enabling detailed vascular mapping in under seven minutes without contrast agents.

An Ultra-High-Resolution 17.2 T MRI Atlas (HypoAtlas) and Multimodal Pipeline to Study the Mouse Hypothalamus: Sexual Dimorphism and Lateralization Insights

MR-μScope: a multi-scale and simultaneous MRI-miniaturized microscopy system for elucidating neurovascular coupling

The paper introduces MR-μScope, a system combining MRI and miniaturized microscopy to study neurovascular coupling across scales, showing vessel-size-dependent responses to stimuli.

Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

This paper introduces a biphasic acclimation protocol for simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice, showing convergent and divergent patterns in brain function between modalities.

Data-driven denoising in spinal cord fMRI with principal component analysis

This paper evaluates a PCA-based denoising method for spinal cord fMRI using a noise ROI, finding that it may not consistently improve group-level activation maps compared to physiological recording-derived regressors.

Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications

This study examines how postmortem intervals affect quantitative MRI signals in unfixed and fixed pig brains, finding that PMI significantly impacts T1 relaxation times but not T2 or T2*.

Biophysical simulations of fMRI responses using realistic microvascular models: insights into distinct hemodynamics in humans and mice

This paper develops a biophysical model to simulate fMRI responses in mice and humans, revealing species-specific hemodynamic differences and conserved vascular asymmetries.

Development of a 24-Channel 3T Phased-Array Coil for fMRI in Awake Monkeys - Mitigating Spatiotemporal Artifacts in Ferumoxytol-Weighted Functional Connectivity Estimation

This paper develops a 24-channel 3T RF coil for fMRI in awake monkeys, improving ferumoxytol-weighted functional connectivity estimation and identifying human-like functional networks.

Does the Brain's E:I Balance Really Shape Long-Range Temporal Correlations? Lessons Learned from 3T MRI

This study investigates if the Hurst exponent of fMRI signals correlates with excitatory-inhibitory balance in humans, finding no association.

Decoding of columnar-level organization across cortical depth using BOLD- and CBV-fMRI at 7 T

The paper uses MVPA to decode ocular dominance columns in V1 across cortical layers using BOLD and CBV-fMRI, finding that macrovascular contributions limit spatial specificity.

Beyond the Canonical HRF: Flexible Temporal Modeling Reveals Unconstrained BOLD Profiles During Naturalistic Viewing

This study shows that using a flexible temporal model instead of the standard HRF improves the alignment of brain activity with naturalistic stimuli features.

High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis

This study uses high-resolution 3D-MRSI to assess neurometabolite differences in youth at risk for psychosis compared to controls, finding elevated tNAA and Ins in specific brain regions.