Cellular Mechanics and Interactions

This study shows that non-muscle myosins NMY-1 and NMY-2 are required for late C. elegans embryonic elongation through redundant roles in epidermal remodeling.

This study shows that focal adhesion distribution affects force balance in epithelial monolayers, revealing non-uniform contractile patterns that alter force transmission.

This study uses cryo-ET to reveal the nanoscale 3D organization of cortical actin in cellular blebs, showing short and straight actin filaments and structural parameters.

This study investigates how biomechanical regulation of cell shapes influences branching morphogenesis in the ureteric bud epithelium, identifying key cellular mechanics involved in branch formation.

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.

This study shows that altering the non-linear elasticity of collagen hydrogels affects cell morphology, migration, and matrix deformation through mechanical interactions with a second polymer component.

This paper describes a method to create elastomeric stencils for controlled stem cell differentiation and pattern formation.

The paper investigates how SARS-CoV-2 spike protein activates calcium and actin dynamics to enable filopodial extension and virus binding through ACE2.

This study develops a continuum model to explain spatial velocity heterogeneity in collective electrotaxis and applies it to design electric field protocols for controlled tissue migration.

The paper investigates structural disorder in Drosophila germband epithelium during body axis elongation, showing that both internal and external stresses contribute to disorder and that disorder levels reflect physical or biological limits.

The paper shows that compressive stress during Drosophila leg development drives apoptosis through lateral tension and Piezo1, contributing to tissue folding.

This study investigates the spatiotemporal regulation of focal adhesions and clathrin-containing adhesion complexes in breast cancer cells, revealing their inverse relationship with membrane tension and distinct roles in cancer progression.

This study shows that lateral confinement controls pericyte shape and migration, with dry friction theory accurately predicting their behavior in vitro.

The paper extends the vertex model to explain how the amnioserosa remains solid during Drosophila dorsal closure despite increased cell shape index.

This study measures how fibroblast mechanical properties change in 2D and 3D collagen gels of varying stiffness, showing increased Young's modulus with stiffer substrates.

The paper demonstrates mechanical coupling between epithelial cells at apical-apical surfaces during implantation, mediated by extracellular matrix and tight junction molecules.

The paper shows that epithelial cells exhibit superdiffusive migration in tissues due to directional memory from velocity coordination and adhesion dynamics, enhancing their range compared to isolated cells.

This paper introduces a trizonal model to predict cancer cell shape transitions under ECM stiffening, revealing three motility zones and their implications for invasion.

This study reveals that CAP is a processive depolymerase of actin filaments, removing subunits from both barbed and pointed ends, and interacts with formin and capping protein.

This paper introduces a microplate-based platform for high-throughput cellular microenvironment screening using protein nanopatterning.

This study investigates whether Rac1 deletion affects SMC proliferation by altering arterial stiffness or differentiation, finding no significant changes in ECM composition, stiffness, or SMC markers.

This study investigates how YAP-mediated mechanogenotypes influence mechanical adaptation of cancer cells during extravasation and organ colonization in vivo.

This study identifies BNIP-2 as a key organizer of focal adhesion nanostructure that enhances signaling and traction force, essential for cardiomyocyte differentiation.

The paper introduces two non-invasive techniques for subcellular biomechanical analysis in vivo, revealing PCP-dependent mechanical gradients during convergent extension.

This study investigates how DDR2 and substrate stiffness affect cancer cell proliferation and transcriptome, revealing distinct regulatory mechanisms.

The paper quantifies cell dynamics by analyzing shape fluctuations on micropatterned substrates, revealing statistical patterns that distinguish cell types and environmental effects.

This study shows that MARK3-mediated phosphorylation of SSH1 is necessary for its release from F-actin and translocation to lamellipodia, enabling polarized cell migration.

This study shows that actin-based nuclear deformations are essential for multiciliated ependymal cell differentiation in mice.

The paper investigates how flies manage mechanical stress during gastrulation, finding two distinct strategies in different dipteran groups to prevent tissue collision.

This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.