Fungal and yeast genetics research

Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans

This study shows that Chr7 trisomy in Candida albicans affects colonization and virulence differently depending on strain background and homolog identity.

Altered stereostructures of the DNA-binding domains in the mutant mating proteins of Ophiocordyceps sinensis and the Cordyceps sinensis insect-fungal complex

This study analyzes DNA-binding domain stereostructures in mating proteins of Ophiocordyceps sinensis and Cordyceps sinensis, showing how amino acid substitutions affect their 3D structures and functions.

PmaI-dependent pH gradients initiate inter- and intraspecies germling fusion in filamentous fungi

This study identifies pH gradients as a signaling mechanism for germling fusion in filamentous fungi, mediated by PmaI ATPase and CgSte3 receptor.

Histone acetylation by SAGA Complex but not by NuA4 Complex is Required for filamentation programme in Candida albicans

The paper shows that SAGA complex's histone acetylation is essential for filamentation in C. albicans, while NuA4's role is less critical.

Harbouring Starships: the accumulation of large horizontal gene transfers in domesticated and pathogenic fungi

This study investigates the role of Starships, large horizontal gene transfers, in domesticated and pathogenic fungi, finding increased Starship content in strains from human-associated environments.

The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development

The paper shows that VeA, a fungal transcription factor, shuttles between the cytoplasm and nucleus during different developmental stages, with nuclear localization required for sexual development and cytoplasmic presence needed for asexual development.

The Molecular Landscape of Cellular Metal Ion Biology

The paper quantifies yeast cell responses to varying metal ions, revealing widespread proteomic and genetic impacts and common metal responsiveness properties.

Responses to temperature shocks in Zymoseptoria tritici reveal specific transcriptional reprogramming and novel candidate genes for thermal adaptation

This study investigates how Zymoseptoria tritici responds to temperature shocks using transcriptomics and GWAS, identifying genes and loci involved in thermal adaptation.

Mechanisms of growth-dependent regulation of the Gin4 kinase

The paper investigates the molecular mechanisms of growth-dependent hyperphosphorylation of the Gin4 kinase in budding yeast, identifying Elm1 and casein kinase I as key regulators.

Functional diversification of the MADS-box gene family in fine-tuning the dimorphic transition of Talaromyces marneffei

The paper identifies functional diversification of MADS-box genes in Talaromyces marneffei, showing mads9 inhibits hyphal-to-yeast transition while mads10 does not.

Convergent expansions of keystone gene families drive metabolic innovation in a major eukaryotic clade

The paper investigates the relationship between gene family expansions and metabolic traits in yeasts, finding that keystone gene families drive multiple metabolic innovations.

Meiotic null MSH2 and SGS1 alleles in S. cerevisiae x S. uvarum hybrids result in near-haploid offspring with mixed parental chromosomal inheritance

The paper investigates hybrid sterility in S. cerevisiae x S. uvarum hybrids using meiotic null alleles, finding that near-haploid offspring with mixed chromosomal inheritance can be recovered despite reduced fertility.

A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus.

This paper describes a cross-species rescue by mating method to study gene essentiality across Saccharomyces species.

Uncovering the principles coordinating systems-level organelle biogenesis with cellular growth

The paper uses hyperspectral imaging of fluorescently labeled yeast cells to analyze how organelle biogenesis correlates with cellular growth rate and size.

Genetic response to light and carbon source variations in Trichoderma harzianum: The key regulatory roles of env1, cre1, and blr2

This study investigates how light and carbon sources affect gene expression in Trichoderma harzianum, identifying env1, cre1, and blr2 as key regulators of metabolic adaptation.

Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage

The paper analyzes gene family evolution across nearly all known Saccharomycotina yeast species, finding distinct evolutionary patterns with gene loss linked to metabolic and genomic changes.

Metabolic and transcriptomic insights into a GalNAc/Man-Specific lectin in yeast fermentation

This study investigates how Cyclina sinensis lectin affects yeast metabolism, showing it enhances ethanol production by altering glycolytic and TCA cycle enzyme expression and metabolite levels.

Intriguing relationship between chromosome I nuclear aneuploidy and mitochondrial intron deletion in yeast

The paper investigates the relationship between nuclear aneuploidy and mitochondrial intron deletion in yeast, finding that aneuploidy promotes reversion of mitochondrial intron mutations.

Balancing doses of EL222 and light improves optogenetic induction of protein production in Komagataella phaffii

This study improves optogenetic control of protein production in K. phaffii by balancing EL222 and light doses, enhancing tunability and flexibility compared to methanol-based induction.

Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in Aspergillus fumigatus

This study shows Rho2 in Aspergillus fumigatus enhances cell wall remodeling and stress resistance against granulocyte attacks, improving survival through upregulation of cell wall biosynthesis.

Saturation transposon mutagenesis enables genome-wide identification of genes required for growth and fluconazole resistance in the human fungal pathogen Cryptococcus neoformans

This paper uses saturation transposon mutagenesis to identify essential genes and drug resistance mechanisms in Cryptococcus neoformans.

Hog1/p38 regulates the integrated stress response (ISR) and global transcriptomics changes in C. neoformans during oxidative stresschanges in C. neoformans during oxidative stress.

The paper investigates the role of Hog1/p38 and Gcn2 pathways in C. neoformans' response to oxidative stress, showing their convergence on transcriptomic changes and stress tolerance.

A novel mechanism of morphogenetic transition in Schizosaccharomyces pombe dependent on the MAPK Spc1 and the transcription factor Atf1 associated with sensing of optimal growth environment

This study identifies a novel mechanism in fission yeast where the MAPK Spc1 and transcription factor Atf1 regulate morphogenetic transitions in response to metabolic and environmental cues.

A BRCT Domain-Containing Protein Induced in Early Phagocytosis Plays a Crucial Role in Mucorales Pathogenesis

The paper identifies virulence genes in Mucorales fungi through transcriptomic analysis and functional validation, showing species-specific effects on virulence in different fungal species.

Frog-killing chytrid fungi deploy different strategies to regulate intracellular pressure in cell types that have or lack a cell wall

This study shows that frog-killing chytrid fungi use different strategies for intracellular pressure regulation in cell types with and without cell walls.

Pseudogymnoascus destructans transcriptional response to chronic copper stress

This study examines the transcriptional response of Pseudogymnoascus destructans to copper stress, identifying differentially expressed genes and potential virulence factors under varying copper conditions.

Giant transposons promote strain heterogeneity in a major fungal pathogen

This study identifies giant transposons called Starships in Aspergillus fumigatus that generate genomic and phenotypic heterogeneity across strains.

Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

The paper identifies Dip2 as a conserved regulator of DAG-based PKC signaling in eukaryotes, showing its role in maintaining specific DAG subpopulations required for PKC-mediated pathways.

Regulation of Phosphatidylinositol-(4,5)-bisphosphate and Active-Rho1p Levels and Distribution is Crucial for Correct Spatio-temporal Cytokinesis and Echinocandin Responses in Candida albicans

This study shows that PI(4,5)P2 and Rho1p regulate cytokinesis and echinocandin response in C. albicans through their spatial distribution and interaction with septins and actomyosin components.

Regulation of the branched-chain amino acid pathway and its crosstalk to carbon metabolism in yeast

The paper investigates how the branched-chain amino acid (BCAA) pathway is regulated during the diauxic shift in yeast and its impact on carbon metabolism.