Stress Responses and Cortisol

A persistent increase in gut permeability correlates with emotional dysregulation following maternal separation in male and female mice.

This study shows that maternal separation increases gut permeability and correlates with anxiety and depression-like behaviors in adult mice, with sex-specific effects.

The effects of chronic social stress on cognitive flexibility in adult female macaques

This study examines the effects of chronic social stress on cognitive flexibility in adult female Rhesus macaques, finding mild deficits in low-ranking individuals compared to high-ranking ones.

The effects of adolescent stress on adult social behavior and basolateral amygdala GABAergic neurons with perineuronal nets depend on prenatal stress history

This study examines how prenatal and adolescent stress affect adult social behavior and GABAergic neurons in the basolateral amygdala, finding that prenatal stress can mitigate some effects of adolescent stress.

Mitochondrial Response to Psychological Stress and Its Medial Prefrontal Biomarker Correlates

The paper investigates the mitochondrial response to psychological stress using salivary cf-mtDNA and brain imaging, finding associations with brain metabolites and cortical thickness.

Sex-specific effects of chronic unpredictable stress on mitochondrial function in the HPA axis in mice

This study examines sex-specific effects of chronic unpredictable stress on mitochondrial function in the HPA axis of mice, finding reduced mitochondrial respiration in females and increased complex II protein in males.

Voluntary eating of saltier food by mice and acute stress each abrogate reductions in a neuroinflammatory marker across sexes

This study examines how high salt diet and acute stress affect neuroinflammation in mice, finding sex-specific and context-dependent effects on Iba1 levels and coping behaviors.

Inhibition of the Microglial Phagocytic Receptor MerTK Underlies ELA-induced Changes in Synapses and Behavior in Male Mice

This study shows that ELA increases excitatory synapses in male mice's PVN by inhibiting microglial MerTK, mimicked by microglial MerTK deletion, but not in females.

Sensory neurostimulation promotes stress resilience with frequency-specificity

This study shows that AV flicker at specific frequencies can mitigate stress-induced changes in mice, with 10Hz effective in males and 40Hz in females.

Male and Female Mice Are Similarly Susceptible to Chronic Nondiscriminatory Social Defeat Stress Despite Differences in Attack Frequency from Aggressor

This study shows female and male mice are equally susceptible to chronic non-discriminatory social defeat stress, despite females receiving fewer attacks, and that susceptibility correlates with impaired reward valuation.

Multimodal assessment of acute stress dynamics using an Aversive Video Paradigm (AVP)

This study assesses the effects of aversive video clips on stress-related psychological, neural, and physiological responses in humans.

Early development of the glucocorticoid stress response in dyeing poison frog tadpoles

This study examines the development of the glucocorticoid stress response in dyeing poison frog tadpoles and finds it develops early in ontogeny, differing from other species due to unique ecological pressures.

Neural Predictors of Functional Genomic Responses to Negative Social Evaluation in Adolescent Females

The paper examines how neural activity in the threat network predicts changes in gene expression related to immune pathways in adolescent females during social evaluation tasks.

Rodent chronic variable stress procedures: a disjunction between stress entity and impact on behaviour

This study examines how variations in chronic variable stress procedures affect behavioral outcomes in mice, finding that longer and more diverse stress regimens reduce effect sizes in certain tests.

Reduced gene dosage of the psychiatric risk gene Cacna1c is associated with impairments in hypothalamic-pituitary-adrenal axis activity in rats

This study shows that reduced Cacna1c gene dosage in rats leads to HPA axis dysfunction and anxiety, suggesting a potential mechanism for psychiatric disorder risk.

Non-obese genetic type 2 diabetes causes brain and behavioral hallmarks of chronic stress

This study shows that non-obese type 2 diabetes causes stress-related brain and behavioral changes, partly through glucocorticoids.

Single-cell transcriptomics yield insights into the stress-immune interplay and inform disease risk

The paper uses single-cell transcriptomics to study stress hormone effects on immune cells and identifies cell-type-specific changes linked to stress-related diseases.

Underappreciated role of environmental enrichment in alleviating depression and anxiety: Quantitative evidence synthesis of rodent models

This study quantitatively synthesizes rodent model data to show environmental enrichment reduces depressive and anxiety-like behaviors by 16% and decreases inter-individual variability by 12%.

Effect of Chronic Stress on Whole Blood Transcriptome: A Meta-Analysis of Publicly Available Datasets from Rodent Models

This paper performs a meta-analysis of three mouse datasets to identify stress-related gene expression changes in whole blood and links them to immune dysregulation and cellular aging.

The Effects of Early Life Pain and Juvenile Fear Conditioning on CRF-Receptor Expression in the Amygdala and Hypothalamus

This study investigates how early life pain and fear conditioning affect CRH receptor expression in brain regions, finding no significant changes in amygdala receptors but modest hypothalamic changes.

Sex-Specific Neural Adaptations to Acute and Chronic Restraint Stress in Mice

This study examines how acute and chronic restraint stress differentially affect neural activation in male and female mice, revealing sex-specific adaptations linked to neuropsychiatric disorder vulnerabilities.

Whole brain dimensional approach identifies networks of stress susceptibility in male and female mice.

The paper identifies sex-specific neuroanatomical and connectomic signatures of stress susceptibility in male and female mice using a phenotype-matched chronic variable stress protocol.

Critical Period Plasticity is Associated withResilience to Short Unpredictable Stress

This study investigates how brain plasticity affects resilience to stress in mice, finding that heightened plasticity in adolescent and SynCAM 1 knockout mice promotes resilience to depressive-like behavior.

Stress during puberty and adulthood pregnancy impact histone acetylation regulators in the hypothalamus

This study shows that stress during puberty and pregnancy alters histone acetylation regulators in the hypothalamus, leading to a blunted stress response.

Prolonged exposure treatment following chronic social defeat stress in mice reduces behavioral stress responses and social avoidance.

Oxytocin may reduce the accumulation and effects of chronic stress: An exploratory study using hair samples

This study examines how hair cortisol and oxytocin levels relate to training load and mental health in female soccer players, finding that oxytocin moderates the relationship between training load and cortisol.

Genetic diversity shapes behavioral outcomes and reveals sex differences in mice exposed to early life stress

The paper investigates how genetic diversity in mice affects behavioral outcomes after early life stress, revealing sex-specific differences in social behavior, anxiety, and reward-seeking.

Glucocorticoid receptors mediate reprogramming of astrocytes in depression.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

Does the evolution of predatory behaviour alter stress response? Insights from a selection experiment on bank voles

This study examines how selection for predatory behavior in bank voles affects stress response, finding altered HPA axis regulation in females.

Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability

This study investigates how early-life stress affects nucleus incertus neurons in rats, finding altered gene expression, dendritic structure, and electrophysiological properties linked to stress and compulsive behavior.

Second-Scale Neural Dynamics Shape Hormonal Outputs in Hypothalamic CRH Neurons

This study investigates how second-scale neural dynamics in CRH neurons translate stress signals into sustained hormonal outputs, showing firing rate over seconds determines CRH release.