Attention Deficit Hyperactivity Disorder

Medication and Developmental Stage Shape the Brain-Age Gap in ADHD

This study shows that brain-age gaps in ADHD vary with medication use and developmental stage, with abnormalities more common in unmedicated children than adolescents.

Exploring the genetic overlap between attention-deficit/hyperactivity disorder (ADHD) and migraine

This study identifies shared genetic variants between ADHD and migraine, showing pleiotropy and associations with neuroimmune and neurodevelopmental pathways.

Rate dependent Effects of AMPH on attentional processes as measured by 5C-CPT task

This study investigates the rate-dependent effects of amphetamine on attentional performance in rats using the 5C-CPT task, finding both direct and inverse relationships between baseline performance and drug-induced changes.

Stimulant medications affect arousal and reward, not attention

This study shows stimulant medications affect brain connectivity in action/motor and reward-related regions, not attention networks, and mimic the effects of sleep.

Developmental deviations of structural connectivity in youths with ADHD predict symptom and treatment outcomes

This study identifies structural connectivity deviations in ADHD youths as biomarkers predicting symptom progression and treatment response.

The School Cafeteria Problem: Disrupted Visuospatial Attention During Multisensory Speech-in-Noise Perception in Children with ADHD

This study examines audiovisual integration and visuospatial attention in children with ADHD during speech-in-noise perception, finding reduced multisensory benefits and altered attention allocation.

Cell type-specific methylome-wide association studies of childhood ADHD symptoms

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

Deep Learning of Brain-Behavior Dimensions Identifies Transdiagnostic Biotypes in Youth with ADHD and Anxiety Disorders

The paper uses deep learning to identify brain-behavior dimensions and biotypes in youth with ADHD and anxiety disorders, revealing distinct symptom profiles and brain development patterns.

Limbic System White Matter in Children and Adolescents with ADHD: A Longitudinal Diffusion MRI Analysis

This study uses diffusion MRI to examine limbic system white matter development in children and adolescents with ADHD, finding reduced microstructural organization and connectivity linked to symptom severity.

Shared and distinct neural signatures of inhibitory control deficits in attention-deficit/hyperactivity disorder and autism

This study identifies shared and distinct neural patterns in inhibitory control deficits between ADHD and ASD using fMRI data.

Functional connectivity differences in adult's ADHD - a MEG study

This study uses MEG to identify frequency-specific functional connectivity differences in adult ADHD, finding hypo-connectivity in high-gamma bands and altered integration in key networks.

Improving Machine Learning Prediction of ADHD Using Gene Set Polygenic Risk Scores and Risk Scores from Genetically Correlated Phenotypes

Expression profile of the ADHD risk gene ADGRL3 during human neurodevelopment and the effects of genetic variation

This study investigates ADGRL3 expression during human neurodevelopment and finds that the rs1397547 SNP is associated with increased ADGRL3 transcription and a unique transcriptional profile in cortical neurons.

Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD

This study identifies common and rare variant risk loci for ADHD in a Hong Kong population, implicating cerebellar development and immune genes.

White matter properties in fronto-parietal tracts predict maladaptive functional activation and deficient response inhibition in ADHD

The paper investigates white matter properties in fronto-parietal tracts and their association with response inhibition deficits in ADHD using diffusion data and a Go/No-go task.

Selective attention and sensitivity to auditory disturbances in a virtually-real Classroom: Comparison of adults with and without AD(H)D

This study compares attention and distractibility in adults with and without AD(H)D using a virtual classroom, finding higher neural responses to irrelevant sounds and reduced speech tracking in AD(H)D individuals.

Reduced occurrence of alpha waves during resting state predicts high ADHD traits in young adults

This study finds that lower alpha wave occurrence during rest predicts higher ADHD traits in young adults using EEG data from a twin sample.

Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD

This study identifies increased temporal variability and reduced spatial stability in neural activity patterns in children with ADHD, correlating with cognitive control deficits and symptom severity.

Neurophysiology of perceptual decision-making and its alterations in attention deficit hyperactivity disorder (ADHD)

This study uses EEG to analyze perceptual decision-making in ADHD, finding altered neural dynamics in attentional selection, sensory evidence accumulation, and response preparation compared to typically developing children.

Latrophilin-3 conditional knockout in tyrosine hydroxylase neurons (Lphn3-Th-Cre) compared with Lphn3 global KO rats: Role of Lphn3 in tyrosine hydroxylase neurons on cognitive and behavioral effects of this ADHD susceptibility gene

This study compares global and conditional Lphn3 knockout rats to assess the role of Lphn3 in tyrosine hydroxylase neurons on ADHD-related behaviors and neuroplasticity.

Dysfunctional oscillatory bursting patterns underlie working memory deficits in adolescents with ADHD

The paper investigates bursting patterns in EEG data from adolescents with ADHD and finds that deviations in alpha/beta and gamma burst dynamics correlate with working memory errors and clinical symptoms.

Inversed association of locus coeruleus MRI integrity with structural volume and its impact on individual's inattentiveness

The paper examines the relationship between locus coeruleus MRI integrity and volume with inattentiveness scores, finding inverse associations and lateralization to the right hemisphere.

Transcriptome profiling of dopaminergic neurons derived from an ADHD induced pluripotent stem cell (iPSC) model

This study profiles transcriptomes of dopaminergic neurons from ADHD and neurotypical iPSCs, identifying DEGs overlapping with ADHD GWAS results and suggesting delayed neuronal maturation.

Right Caudate Volume and Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder (ADHD)

This study examines the relationship between caudate and putamen volumes and executive functions in children with ADHD, finding no volumetric differences but a correlation between right caudate volume and parent-reported emotion regulation.

Identifying Developmental Changes in Functional Brain Connectivity Associated with Cognitive Functioning in Children and Adolescents with ADHD

The paper uses machine learning on fMRI data to predict cognitive abilities in children and adolescents with ADHD, finding distinct neural mechanisms in different age groups.

Visual network modularity and communication alterations in ADHD subtypes: evidence from source localized EEG and graph theoretical analysis

This study uses EEG and graph theory to analyze brain network modularity and communication in ADHD subtypes, finding reduced visual network modularity and communication in ADHD groups compared to controls.

Abscisic Acid rescues behavior in adult female mice in Attention Deficit Disorder with Hyperactivity model of dopamine depletion by regulating microglia and vesicular GABA transporter

This study shows that abscisic acid reduces hyperactivity and impulsivity in adult female mice with dopamine depletion by restoring microglia function and the E/I ratio.

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: Utilizing electronic health records in a Phenome-Wide Association Study

This study identifies 80 medical conditions associated with ADHD genetic liability in adults without ADHD diagnosis using EHR data.

Normative growth modeling of brain morphology reveals neuroanatomical heterogeneity and biological subtypes in children with ADHD

This study identifies two distinct ADHD biotypes based on brain morphology, showing different treatment responses and genetic correlates.

Disentangling the shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD

This paper identifies shared genetic risk loci between ADHD, cannabis use disorder, and cannabis use, and predicts cannabis use disorder risk in ADHD using polygenic scores.