Growth Hormone and Insulin-like Growth Factors

Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

This study investigates the metabolic and gene expression effects of gain- and loss-of-function STAT5B variants in mice, revealing distinct impacts on lipid metabolism and hepatic sexual dimorphism.

Evolution of Insulin, Insulin-like Growth Factor, and Their Cognate Receptors in Vertebrates, Invertebrates, and Viruses

This study analyzes the evolutionary origins and molecular diversification of insulin, IGFs, and their receptors across vertebrates, invertebrates, and viruses, revealing lineage-specific adaptations and conserved features.

INFLUENCE OF LIFESTYLE ON BRAIN SENSITIVITY TO CIRCULATING INSULIN-LIKE GROWTH FACTOR 1

The paper investigates how lifestyle factors like isolation and high-fat diet affect brain sensitivity to IGF-1 in mice, showing reduced neuronal responses to systemic IGF-1 and linking this to mood disturbances.

Semaglutide interferes with postnatal development of juvenile mice with compromised growth

This study examines the effects of semaglutide on growth and metabolism in juvenile mice, finding it lowers blood glucose in normally growing mice but worsens growth impairment in stunted juveniles.

Growth Hormone Excess Drives Liver Aging via increased Glycation stress

This study shows that growth hormone excess in mice causes liver aging by increasing glycation stress, which can be reversed with glycation-lowering compounds.

Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity

This study identifies two functional IGF-1 coding variants in centenarians that may contribute to exceptional longevity by impairing IGF-1R activity and reducing circulating IGF-1 levels.

Isolating the Direct Effects of Growth Hormone on Lifespan and Metabolism

This study shows that knocking out the GH gene in mice increases lifespan and alters metabolic fuel utilization, directly linking GH to aging mechanisms.

Using site-directed mutagenesis to further the understanding of insulin receptor-insulin like growth factor-1 receptor heterodimer structure.

The paper uses site-directed mutagenesis to identify key residues involved in IR-IGF1R hybrid receptor formation, showing mutations reduce hybrid affinity and support rational drug design.

Evolution of the Growth Hormone Gene Duplication in Passerine Birds

The paper investigates the molecular evolution of duplicated growth hormone genes in passerine birds, finding evidence of positive selection and functional divergence.

Constitutively active STAT5b feminizes mouse liver gene expression

This study shows that constitutively active STAT5b induces female-biased gene expression in male mouse liver, mimicking GH effects, but also causes histopathology at high doses.

Protein QTL analysis of IGF-I and its binding proteins provides insights into growth biology

The paper performs protein QTL analysis of IGF-I and its binding proteins in children to explore genetic regulation and growth mechanisms.

Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: observational and Mendelian randomization analyses

This study examines the association between IGF-1 and breast cancer risk using observational and Mendelian randomization analyses, finding a positive association and suggesting a causal relationship.

Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth

The paper investigates catch-up growth in fetal mice after inducing cell cycle arrest in chondrocytes, revealing local and systemic compensatory mechanisms that maintain body proportions.