Growth Hormone and Insulin-like Growth Factors

Synthetic inhibitors of pregnancy-associated plasma protein-A regulate IGF-1 signaling in vitro and in vivo

This study develops synthetic PAPP-A inhibitors that modulate IGF signaling in vitro and in vivo, showing efficacy comparable to natural inhibitors.

A Tumor-Pituitary-Stromal Axis Promotes Colorectal Cancer Progression

This study identifies a tumor-pituitary-stromal signaling axis that promotes colorectal cancer progression by enhancing pituitary growth hormone output and fibroblast-mediated tumor promotion.

Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling

This study identifies STAT5-IGF1 signaling as a pathway driven by constitutive PDGFRb activation that causes connective tissue overgrowth in mice, with implications for human disease.

Reproductive experience promotes permanent body growth independently of growth hormone

This study shows that reproductive experience leads to permanent body growth in mice and humans, independent of growth hormone.

Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

This study investigates the metabolic and gene expression effects of gain- and loss-of-function STAT5B variants in mice, revealing distinct impacts on lipid metabolism and hepatic sexual dimorphism.

Stem cell control and cancer initiation by an autocrine, injury-activated Igf complex

The paper identifies Igf2 as an injury-activated mitogen for neuroendocrine stem cells and shows its role in cancer initiation through receptor activation and Rb repression.

Harmonization of IGF1 immunoassay methods using an LC-MS/MS method and associated normative dataset.

The paper generates and tests IGF1 reference materials for harmonizing immunoassay and LC-MS/MS methods and establishes age-related reference intervals using a biobank dataset.

Evolution of Insulin, Insulin-like Growth Factor, and Their Cognate Receptors in Vertebrates, Invertebrates, and Viruses

This study analyzes the evolutionary origins and molecular diversification of insulin, IGFs, and their receptors across vertebrates, invertebrates, and viruses, revealing lineage-specific adaptations and conserved features.

Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxia

This study identifies Stc2a as a hypoxia-induced factor that inhibits IGF signaling to prioritize survival over growth in zebrafish.

INFLUENCE OF LIFESTYLE ON BRAIN SENSITIVITY TO CIRCULATING INSULIN-LIKE GROWTH FACTOR 1

The paper investigates how lifestyle factors like isolation and high-fat diet affect brain sensitivity to IGF-1 in mice, showing reduced neuronal responses to systemic IGF-1 and linking this to mood disturbances.

Semaglutide interferes with postnatal development of juvenile mice with compromised growth

This study examines the effects of semaglutide on growth and metabolism in juvenile mice, finding it lowers blood glucose in normally growing mice but worsens growth impairment in stunted juveniles.

Growth Hormone Excess Drives Liver Aging via increased Glycation stress

This study shows that growth hormone excess in mice causes liver aging by increasing glycation stress, which can be reversed with glycation-lowering compounds.

Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity

This study identifies two functional IGF-1 coding variants in centenarians that may contribute to exceptional longevity by impairing IGF-1R activity and reducing circulating IGF-1 levels.

Structural and Evolutionary Analysis of Human Growth Hormone Variants

The paper analyzes human growth hormone variants to identify critical residues for GH-GHR interaction and disease-causing mutations.

Isolating the Direct Effects of Growth Hormone on Lifespan and Metabolism

This study shows that knocking out the GH gene in mice increases lifespan and alters metabolic fuel utilization, directly linking GH to aging mechanisms.

Using site-directed mutagenesis to further the understanding of insulin receptor-insulin like growth factor-1 receptor heterodimer structure.

The paper uses site-directed mutagenesis to identify key residues involved in IR-IGF1R hybrid receptor formation, showing mutations reduce hybrid affinity and support rational drug design.

A long-acting prolactin to combat lactation insufficiency

This paper engineers a long-acting prolactin variant to enhance lactation, showing it increases milk production and restores pup growth in mice.

Evolution of the Growth Hormone Gene Duplication in Passerine Birds

The paper investigates the molecular evolution of duplicated growth hormone genes in passerine birds, finding evidence of positive selection and functional divergence.

Constitutively active STAT5b feminizes mouse liver gene expression

This study shows that constitutively active STAT5b induces female-biased gene expression in male mouse liver, mimicking GH effects, but also causes histopathology at high doses.

Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice

This study shows that reducing IGF-1R in adult hippocampal neurons impairs spatial learning and memory in male mice but not females, with structural changes in dendritic boutons and altered signaling pathways.

The growth hormone gene has evolved independently in African Pygmy Mouse Mus minutoides

The paper examines the evolution of the growth hormone gene in African Pygmy Mouse, finding it diverged earlier and may have evolved independently with different functions.

Protein QTL analysis of IGF-I and its binding proteins provides insights into growth biology

The paper performs protein QTL analysis of IGF-I and its binding proteins in children to explore genetic regulation and growth mechanisms.

Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: observational and Mendelian randomization analyses

This study examines the association between IGF-1 and breast cancer risk using observational and Mendelian randomization analyses, finding a positive association and suggesting a causal relationship.

The metalloproteinase Papp-aa functions as a molecular switch linking IGF signaling to adaptive epithelial growth

The paper identifies Papp-aa as a [Ca2+]-regulated molecular switch that links IGF signaling to ionocyte reactivation and bone calcification in zebrafish.

Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency

The paper establishes an IGHD2 mouse model to study GH deficiency, finding reduced Ghrhr and Gh promoter activities due to decreased nuclear CREB3L2 levels, revealing a novel molecular mechanism.

Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth

The paper investigates catch-up growth in fetal mice after inducing cell cycle arrest in chondrocytes, revealing local and systemic compensatory mechanisms that maintain body proportions.