Estrogen and related hormone effects

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

This study identifies TRPS1 as a regulator of ER binding and gene expression in luminal breast cancer, showing its role in chromatin accessibility and tumor progression.

The paper investigates how different GR ligands affect coregulator recruitment, finding that antagonists and selective modulators reduce interactions with p300/CBP and the Mediator complex compared to full agonists.

This study shows that GR co-expression enhances MR transcriptional activity in response to aldosterone, even without glucocorticoids.

The paper shows that estradiol concentration changes the chromatin binding sites of the estrogen receptor, affecting its localization and interaction with DNA motifs.

The paper profiles hippocampal transcriptomes across estrous cycles in mice, identifies estrous-responsive genes, and shows Cnih3 deletion disrupts estrous-specific gene expression patterns.

The paper uses an EcR-binding fragment to study how ecdysone (20E) switches EcR from repression to activation in larval wing discs, revealing spatial and target-specific regulation.

This study shows HNF4A is essential for liver-specific GR action, with HNF4A regulating GR binding sites and transcriptional response to glucocorticoids in the liver.

The paper identifies CORO2A as the expression quantitative trait gene underlying Estq1, showing its role in controlling uterine responsiveness to estradiol through haploinsufficiency.

This study maps the dynamic signalling network in breast cancer cells responding to progesterone using antibody microarrays and phosphoproteomics, revealing new proteins and pathway connections.

This study identifies ER-regulated genes in a sexually dimorphic neural circuit, showing ER induces a neurodevelopmental gene program and interacts with Nfix to regulate male-biased gene expression.

The paper identifies the CCM signaling complex (CSC) as a master regulator of progestin homeostasis and signaling, and reports serum biomarkers for predicting hemorrhagic events in CCM pathogenesis.

The paper identifies a novel signaling network involving the CCM signaling complex that couples classic and non-classic progesterone receptor pathways, showing how disruptions in this balance may increase breast cancer risk.

This paper demonstrates that prostaglandins competitively inhibit cortisol binding to glucocorticoid receptors, affecting cellular responses to stress hormones.

The paper investigates how estrogen and tamoxifen affect complement proteins in the hippocampus of ovariectomized rats, showing reduced inflammatory markers with estrogen therapy.

This study investigates how a GATA3 mutation affects the transcriptional network involving ER, FOXA1, and GATA3, showing disrupted cooperation and altered chromatin localization.

The paper identifies 2’, 3’, 4’-trihydroxychalcone (CC7) as an estrogen receptor ligand that modulates estradiol's effects, potentially improving the safety of menopausal hormone therapy.