Estrogen and related hormone effects

Estriol is a Stronger Transcriptional Activator than is either 17beta-Estradiol or Estrone of Hu-man and Elephant Shark Estrogen Receptor-alpha and Estrogen Receptor-beta transfected into COS-7 Cells

The paper compares the transcriptional activation of estrogen receptors by estrone, estradiol, and estriol in different cell lines and species, finding that estriol can be more active than estradiol under certain conditions.

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer

The paper identifies genomic features affecting ERα binding and gene expression in endometrial cancer, finding cell-type-specific transcription factors and distinct predictive features compared to breast cancer.

In vivo CRISPR screening links NFKB1 to endocrine resistance in ER⁺ breast cancer

The paper identifies NFKB1 as a suppressor of endocrine resistance in ER⁺ breast cancer through in vivo CRISPR screening and shows that its loss activates NF-κB signaling, leading to resistance to endocrine therapy.

Asymmetric Cross-Reactivity of Nuclear Receptors Reveals an Evolutionary Buffer Between Estrogen and Androgen Signaling

The paper uses deep learning to show estradiol binds androgen receptors more strongly than testosterone, revealing evolutionary conservation and potential therapeutic implications.

A bifunctional optical reporter for tracking estrogen response dynamics in neurons

This paper introduces a bifunctional optical reporter, neuro-seeER, to track estrogen response dynamics in neurons in vivo and demonstrates its utility in capturing both exogenous and endogenous estrogen responses.

Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer

This study shows vandetanib enhances tamoxifen sensitivity in ER+ breast cancer by reprogramming ER gene regulation and kinase networks, identifying adaptive resistance pathways and response signatures.

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.

RNA Sequencing in Adult Drosophila Females Identifies Estrogen-Related Receptor-Dependent Transcriptional Changes in Metabolism, DNA Replication, and Translation

This study uses RNA sequencing to identify ERR-dependent transcriptional changes in adult Drosophila females, revealing sex-specific effects on metabolism, DNA replication, and translation.

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

This study shows that ERβ activation with DPN improves metabolic outcomes in postmenopausal rats by remodeling liver lipid metabolism and enhancing ketone body production.

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and Tamoxifen in a luminal A breast cancer model

This study shows PAK1 activation leads to different resistance mechanisms against Tamoxifen and aromatase inhibitors in luminal A breast cancer by affecting apoptosis and proliferation through distinct pathways.

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation

This study shows that progesterone receptors (PR) interact with mutant ESR1 variants in ER+ breast cancer, driving CSC expansion and UPR activation, which can be targeted therapeutically.

Androgen receptor interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer.

This study identifies cytoplasmic androgen receptor (AR) localization and novel AR protein interactions in AI-resistant breast cancer, linking them to metabolic shifts and poor prognosis.

Transcriptional Activation of Estrogen Receptor-alpha and Estrogen Receptor-beta from Elephant Shark (Callorhynchus milii)

The paper studies estrogen receptor activation in elephant shark, finding three active ER genes and one unresponsive gene, with similar estrogen responses to humans.

Glucocorticoid-induced proteome and phosphoproteome changes in breast cancer cell lines

This study uses mass spectrometry to analyze proteome and phosphoproteome changes in breast cancer cell lines after glucocorticoid treatment, revealing GR-dependent responses and noncanonical TFs and kinases involved in metastasis.

Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour

This study shows that Egr1 overexpression induces sex-specific changes in neuronal chromatin, gene expression, and behavior in female rodents, mimicking high-oestrogenic phases and affecting hormone-depleted females.

Chlorpyrifos and tamoxifen co-pretreatment promotes stem-like phenotype and upregulation of anti-estrogen therapy resistance markers in ERα breast cancer cells

Does sex matter in neurons response to hypoxic stress?

This study examines sex differences in neuronal response to hypoxia, finding that estrogen modulates network activity but does not provide long-term neuroprotection.

The multimerization pathway of the glucocorticoid receptor

The paper presents a new crystal structure of agonist-bound GR-LBD and proposes a model for GR multimerization, reconciling structural and functional data on glucocorticoid resistance.

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape

This study investigates ESR1 and estrogen-driven transcription in human endometrial stromal cells using transcriptome, cistrome, and chromatin landscape data to identify gene regulation and its implications in decidualization and endometrial cancer.

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

Expression of MMP-11, an estrogen-suppressed gene in MCF-7 cells, is elevated upon acquisition of tamoxifen resistance

This study shows that estrogen suppresses MMP-11 in MCF-7 cells, but tamoxifen resistance leads to increased MMP-11 expression, suggesting a role in drug resistance and tumor aggressiveness.

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

LNS8801: An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development

This paper identifies LNS8801, a pure enantiomer of G-1 that acts as a GPER agonist, showing cancer suppression in preclinical models and potential as a therapeutic with a predictive biomarker.

Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complement

The paper shows oestrogen affects B cell class-switching only in individuals with an XX chromosomal background.

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells

This study investigates how a novel SERM, T6I-29, downregulates DKK1 in Y537S ESR1 mutant breast cancer cells and identifies DKK1 as a potential therapeutic target.

Exploration of the Metabolomic Mechanisms of Postmenopausal Hypertension Induced by Low Estrogen State

This study investigates the metabolomic mechanisms of postmenopausal hypertension in rats, identifying L-AABA as a potential biomarker and linking low estrogen to altered sugar metabolism and vascular changes.

Intracellular Retention of Estradiol is Mediated by GRAM Domain Containing Protein ASTER-B in Breast Cancer Cells

This study identifies ASTER-B as a mediator of intracellular estradiol retention in breast cancer cells, which supports estrogen receptor-dependent gene expression and cell growth.