Estrogen and related hormone effects

CCM signaling complex (CSC) is a master regulator governing homeostasis of progestins and their mediated signaling cascades

The paper identifies the CCM signaling complex (CSC) as a master regulator of progestin homeostasis and signaling, and reports serum biomarkers for predicting hemorrhagic events in CCM pathogenesis.

CCM signaling complex (CSC) coupling both classic and non-classic progesterone receptor signaling

The paper identifies a novel signaling network involving the CCM signaling complex that couples classic and non-classic progesterone receptor pathways, showing how disruptions in this balance may increase breast cancer risk.

Prenatal aromatase inhibition alters postnatal immune function in domestic chickens (Gallus gallus)

This study investigates whether prenatal testosterone exposure affects immune function in chickens via aromatase-mediated conversion to estradiol, finding that inhibiting aromatase increases immune indicators.

ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells

This study shows ETV4 is essential for estrogen signaling and growth in endometrial cancer cells by enabling ER binding and nuclear translocation.

Competitive Inhibition of Cortisol by Prostaglandins at the Ligand Binding Domain of Glucocorticoid Receptors

This paper demonstrates that prostaglandins competitively inhibit cortisol binding to glucocorticoid receptors, affecting cellular responses to stress hormones.

Preliminary Evidence of the role of estrogen and tamoxifen-induced regulation of complement proteins in rat hippocampus

The paper investigates how estrogen and tamoxifen affect complement proteins in the hippocampus of ovariectomized rats, showing reduced inflammatory markers with estrogen therapy.

Estrogen receptor alpha controls gene expression via translational offsetting

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.

EREFinder: Genome-wide detection of estrogen response elements

ERFinder detects estrogen response elements across the human genome and shows these regions are enriched near estrogen-responsive genes.

GATA3 mutation disrupts a functional network governed by estrogen receptor, FOXA1 and GATA3

This study investigates how a GATA3 mutation affects the transcriptional network involving ER, FOXA1, and GATA3, showing disrupted cooperation and altered chromatin localization.

2’, 3’, 4’-trihydroxychalcone is an Estrogen Receptor Ligand Which Modulates the Activity of 17β-estradiol

The paper identifies 2’, 3’, 4’-trihydroxychalcone (CC7) as an estrogen receptor ligand that modulates estradiol's effects, potentially improving the safety of menopausal hormone therapy.

Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells

This study uses single-cell transcriptomics to show estrogen signaling enhances the mitochondrial folate pathway, supporting purine and polyamine synthesis in breast cancer cells.

Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells

The paper shows that the unliganded progesterone receptor (PR) maintains ESR1 expression and DNA methylation in hormone-deprived breast cancer cells, and that PR depletion leads to increased promoter methylation and reduced ESR1 expression.

Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3

This study shows that estradiol induces afadin trafficking between synaptic and nuclear compartments, which is required for histone H3 phosphorylation at serine 10.