Advanced Drug Delivery Systems

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix

This study develops a hydrogel-based vaccine delivery system that enhances immune responses and reduces reactogenicity in aged mice compared to Shingrix.

In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

The paper develops a microfluidic device for precise intranasal drug delivery in freely-moving mice and validates its use for studying cocaine's effects.

Formulation Development of Topical Inserts Containing Doxycycline and Doxycycline Combined with Tenofovir Alafenamide and Elvitegravir for the Prevention of Sexually Transmitted Infections

This paper develops single and combined topical inserts for bacterial STI and HIV prevention, showing effective drug release and stability.

Intrinsically Disordered Protein Coating for Oral Delivery of Peptide Drugs

This paper introduces a synthetic intrinsically disordered protein coating that enhances oral delivery of peptide drugs by protecting them from gastric acid and enabling targeted intestinal release.

Nose-to-Brain Administration of Cannabidiol-Loaded Polymeric Micelles Improves the Core Behavioral Symptoms of Autism Spectrum Disorder

This study develops CBD-loaded polymeric micelles for nose-to-brain delivery in ASD, showing improved brain CBD concentration and behavioral symptom improvement in a rat model.

Synthetic Mucus Biomaterials Enable Localized Therapeutic Antibody Delivery in Inflammatory Bowel Disease

This study develops synthetic mucin-based hydrogels for localized delivery of anti-TNF- antibodies in IBD, showing improved retention and reduced systemic exposure.

Nanoparticle-in-Microparticle Oral Delivery System Based on Drug-Loaded Polymeric Micelles

This paper develops an oral drug delivery system using drug-loaded nanogels encapsulated in a mucoadhesive shell, showing improved controlled release and oral half-life compared to free drug.

Identification and Validation of Small Molecules with Mucin-Selective Regiospecific Binding in the Gastrointestinal Tract

This study identifies small molecules that selectively bind to mucins in the gastrointestinal tract, enhancing localized drug delivery to the small intestine and stomach.

Taguchi/Machine Learning Hybrid Framework for Optimization of Particulate Drug Delivery Systems

The paper develops a hybrid Taguchi/machine learning framework to optimize particulate drug delivery systems, achieving high predictive accuracy and revealing key formulation factors.

A Strategic Blend of Stabilizing Polymers to Control Particle Surface Charge for Enhanced Mucus Transport and Cell Binding

The paper develops MECS NPs with controlled surface charge to enhance mucus transport and cell binding for improved mucosal drug delivery.

A meta-analysis of in vitro release of hydrophilictherapeutics from contact lenses using mathematicalmodeling

The paper develops a mathematical model and statistical analysis to predict therapeutic release from contact lenses based on lens and drug properties.

Diet gel-based oral drug delivery system for controlled dosing of small molecules for microglia depletion and inducible Cre recombination in mice

This study develops a diet gel-based oral drug delivery system for controlled dosing of PLX5622 and Tamoxifen in mice, achieving high microglia depletion and inducible Cre recombination.

Intranasal sertraline for the investigation of nose-to-brain delivery to mitigate systemic exposure

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

Photocrosslinked mucoadhesive hyaluronic acid hydrogel for transmucosal drug delivery

This study develops a photocrosslinked hyaluronic acid hydrogel for nasal drug delivery, showing improved mucoadhesion and stability compared to uncrosslinked versions.

Performance Evaluation of Ciprofloxacin loaded Micellar Bioconjugate Carrier for Eradication of Bacterial Biofilms

This study evaluates a ciprofloxacin-loaded micellar bioconjugate carrier for eradicating bacterial biofilms, showing enhanced antibiofilm activity under acidic conditions.

Rapid in situ forming PEG hydrogels for mucosal drug delivery

This paper develops rapid in situ forming PEG hydrogels for mucosal drug delivery that degrade naturally and adhere to mucus-coated tissues.

The limitation of lipidation: conversion of semaglutide from once-weekly to once-monthly dosing

This study develops a once-monthly dosing form of semaglutide using hydrogel microspheres, showing equivalent weight loss to daily dosing in mice and simulating human efficacy.

Optimizing The Fabrication Of Shape-Defined Microparticles For Sustained Drug Delivery: The 'Less Is More' Paradigm

This study optimizes PLGA microparticle fabrication by adjusting polymer content and cleaning steps, finding lower PLGA content improves yield, encapsulation, and controlled drug release.

A novel maxillofacial technique to deliver drugs to the visual pathway, the optic nerve and the retina using the glymphatic system.

This study evaluates a novel maxillofacial drug delivery technique for targeting the retina, optic nerve, and brain via the glymphatic system, showing it is effective compared to traditional methods.

Efficient Hydrophilic Small Molecule Delivery To Retinal Cell Lines Using Solid Lipid Nanoparticle Containing Gel Core

This study develops a solid lipid nanoparticle formulation for efficient delivery of hydrophilic drugs to retinal cells, showing improved encapsulation efficiency and cellular uptake.

A NEW TECHNIQUE AND DEVICE FOR CONTROLLED AND CONTINUOUS DRUG DELIVERY INTO THE BRAIN. A PROOF OF CONCEPT STUDY.

This study demonstrates a novel technique and device for controlled and continuous drug delivery into the brain without surgical intervention, showing increased drug levels in brain regions and ex vivo models.