Sleep and Wakefulness Research

Theta activity during encoding interacts with NREM sleep oscillations to predict memory generalization

Behavioral and brain responses to verbal stimuli reveal transient periods of cognitive integration of external world in all sleep stages

The paper investigates behavioral responses to verbal stimuli in sleep stages, finding reactivity in all stages except slow-wave sleep in healthy volunteers.

REM sleep promotes bidirectional plasticity in developing visual cortex in vivo

The paper investigates the role of REM sleep in ocular dominance plasticity in layer 2/3 neurons during the visual critical period using 2-photon calcium imaging in mice.

Spindle - slow oscillation coupling correlates with memory performance and connectivity changes in a hippocampal network after sleep

This study examines how spindle-slow oscillation coupling during sleep relates to memory performance and changes in hippocampal network connectivity after spatial learning.

Topographical relocation of adolescent sleep spindles reveals a new maturational pattern of the human brain

The paper examines adolescent sleep spindle topography and finds a shift from central to posterior regions for fast spindles, suggesting an anterior-to-posterior maturation pattern.

Experimental and computational analysis of REM sleep distributed cortical activity in mice

The paper analyzes REM sleep activity in mice using experimental data and a computational model, finding SWA is prominent in somatosensory areas and linked to reduced cortical responsiveness.

Human spindle variability

The paper shows that sleep spindles vary continuously across multiple dimensions rather than being strictly divided into slow and fast categories.

Single acoustic closed loop stimulation in mice to modulate hippocampo-thalamo-cortical activity and performance

This study uses closed-loop acoustic stimulation in mice to explore its effects on hippocampo-thalamo-cortical activity and memory retention during sleep.

Orexin cells efficiently decode blood glucose dynamics to drive adaptive behavior

This study shows that orexin neurons decode blood glucose dynamics to drive adaptive behavior in mice by tracking glucose gradients and generating neural adaptations.

Sleep loss disrupts the neural signature of successful learning

This study investigates how sleep and sleep deprivation affect memory consolidation and learning, finding that sleep supports memory but not necessarily consolidation's role in new learning.

Do orexin/hypocretin neurons track sensory, cognitive, or motor information?

The paper investigates whether hypocretin/orexin neurons track sensory, cognitive, or motor information by analyzing their activity during sound cues and reward outcomes.

Sound disrupts sleep-associated brain oscillations inrodents according to its meaning

The paper shows that sounds with different meanings affect sleep-associated brain oscillations in mice, with aversive sounds causing more significant changes than neutral ones.

Sleep Disruption Selectively Weakens Reactivated Memories

This study shows that sleep disruption can weaken reactivated memories, contrasting with the typical strengthening effect, suggesting memory reactivation can either strengthen or weaken memories based on sleep conditions.

Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice

This study examines how different morphine withdrawal paradigms affect sleep behavior in male and female mice, finding sex-specific differences and highlighting the 3-day precipitated withdrawal model as most impactful.

Normative sleep spindle database and findings from 772 healthy children from birth through 18 years

The paper creates a normative sleep spindle database from 772 healthy children and shows age-specific patterns in spindle features across development.

Memory reactivation in slow wave sleep enhances relational learning

This study shows that targeted memory reactivation during slow wave sleep enhances inferential thinking in a transitive inference task, particularly when applied during the Up-phase of the slow oscillation.

Microglial TNFα orchestrates brain phosphorylation during the sleep period and controls homeostatic sleep.

This study shows microglial TNFα regulates brain phosphorylation during sleep, affecting sleep need and duration through synaptic proteins.

Sleep Deprivation Induces Acute Dissociation via Altered EEG Rhythms Expression and Connectivity.

This study investigates how acute sleep deprivation affects dissociative experiences and finds that it increases dissociative states through altered EEG rhythms and connectivity.

Visuomotor adaptation modulates the clustering of sleep spindles into trains

This paper shows that visuomotor adaptation increases sleep spindle clustering into trains, which correlates with memory retention and spindle-SO coupling.

Five hours total sleep deprivation does not affect CA1 dendritic length or spine density

This study investigates the effects of five hours of sleep deprivation on hippocampal CA1 pyramidal neurons and finds no changes in dendritic length or spine density.

Sepsis-induced brain state instability

This study examines sepsis-induced instability in brain oscillatory states in a rat model, finding increased state transitions and altered power spectra in EEG data.

Ongoing neural oscillations predict the post-stimulus outcome of closed loop auditory stimulation during slow-wave sleep.

This study uses classifiers to predict the effectiveness of closed-loop auditory stimulation during slow-wave sleep based on ongoing neural oscillations.

Physiological alterations in microglial morphology associate with the sleep-wake cycle in a brain region-specific manner

This study shows that microglial morphology changes with the sleep-wake cycle in a brain region-specific manner, with cortical microglia showing a negative correlation with sleep slow wave activity.

Regional variation in cholinergic terminal activity determines the non-uniform occurrence of cortical slow-wave activity during REM sleep

The paper identifies regional differences in cholinergic terminal activity associated with slow-wave activity in specific cortical areas during REM sleep in mice.

Recovery of consolidation after sleep following experimental stroke - interaction of slow waves, spindles and GABA

This study shows that sleep-dependent memory processing is altered after stroke in rats, with impaired spindle coupling to slow oscillations, and that reducing GABA can restore physiological sleep states and improve recovery.

Ketamine and sleep modulate neural complexity dynamics in cats

This study examines how ketamine and sleep stages affect neural complexity in cats using Lempel-Ziv compression, finding dose-dependent changes and differences across brain regions.

The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice

This study compares the development of narcoleptic symptoms in male and female orexin-tTA; TetO-DTA mice, finding females develop symptoms faster but both sexes show similar symptoms by week 6.

Slow oscillation-spindle coupling strength predicts real-life gross-motor learning in adolescents and adults

The paper shows that stronger coupling between slow oscillations and spindles during sleep predicts better motor learning in adolescents and adults.

Orexin action on the dopaminergic system modulates theta during REM sleep and wakefulness

This study investigates the role of orexin receptors in modulating theta oscillations in dopaminergic neurons during wakefulness and REM sleep, finding that OXR2 loss increases theta power and alters coupling with fast-gamma waves.

Delta oscillations coordinate intra-cerebellar and cerebello-hippocampal network dynamics during sleep

This study identifies cerebellar delta oscillations as a temporal coordinator of intra-cerebellar and cerebello-hippocampal network dynamics during sleep.