Sleep and Wakefulness Research

Sources of variation in the spectral slope of the sleep EEG

The paper replicates and extends findings on EEG spectral slope variation across sleep states in a large sample, identifying factors influencing slope estimates and their relationship to sleep parameters.

Cortical ripples during NREM sleep and waking in humans

This study shows cortical ripples occur during human NREM sleep and waking with similar characteristics to hippocampal ripples, associated with upstates, spindles, and unit co-firing, suggesting a role in memory consolidation.

Electrophysiological characterization of medial preoptic neurons in lactating rats and its modulation by hypocretin-1

This study examines the electrophysiological properties of medial preoptic area neurons in lactating and virgin rats and how they respond to hypocretin-1.

Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase

This study identifies a short isoform of SLP/SIK3 and shows both long and short isoforms contribute to increased sleep quantity and intensity in Sleepy mice.

Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep

The paper uses single-cell RNA sequencing and cell-type specific proteomics to study sleep's molecular effects, finding cell-specific transcriptional, translational, and post-translational responses to sleep need.

Mutual interaction between Visual Homeostatic Plasticity and Sleep in Adult Humans

The paper shows that non-REM sleep stabilizes visual homeostatic plasticity in adults, with sleep spindle density and slow oscillations correlating with plasticity outcomes.

Reconfigurations in brain networks upon awakening from slow wave sleep: Interventions and implications in neural communication

This study investigates how blue-enriched light affects neural network reconfiguration during awakening from slow wave sleep, showing partial acceleration of long-range communication prioritization.

Resting-state aperiodic neural activity as a novel objective marker of daytime somnolence

The paper investigates aperiodic neural activity as a marker for excessive daytime somnolence, finding it predictive of EDS with high accuracy using logistic regression.

Context matters: Changes in memory over a period of sleep are driven by encoding context

This study shows that memory changes during sleep are correlated among contextually linked objects, unlike during wake.

Atypical hypnotic compound ML297 restores sleep architecture following emotionally-valenced learning, to promote memory consolidation and hippocampal network activation during recall

ML297, a GIRK1 activator, restores sleep architecture after fear learning, enhancing memory consolidation and hippocampal network activity during recall.

Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions

This study investigates how locus coeruleus-norepinephrine system activity and astrocytic responses change during sleep states, revealing dynamic fluctuations in norepinephrine levels and their relationship to sleep processes.

Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics

This study examines how different auditory stimulation approaches during sleep affect brain oscillations and cardiovascular dynamics, finding increased slow wave activity and related cardiovascular changes.

Impaired top-down auditory processing despite extensive single-neuron responses during human sleep

The paper investigates auditory processing during sleep using human epilepsy patients' recordings, finding robust neural responses despite reduced alpha-beta power, suggesting impaired top-down processing.

Reinstatement of emotional associations during human sleep: an intracranial EEG study

This study investigates how emotional memories are consolidated during sleep using intracranial EEG in epileptic patients, finding enhanced slow-oscillation and spindle activity in response to emotional stimuli.

The Rise and Fall of Slow Wave Tides: Vacillations of Slow Wave/Spindle Coupling Shift the Composition of Slow Wave Activity Through Sleep Cycles in Accordance with Depth of Sleep

This study examines how slow wave/spindle coupling changes across NREM sleep cycles and how these changes relate to sleep depth and age-related differences in SWA composition.

Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder

This study finds increased sleep spindle activity in PTSD patients, correlating with intrusive memory symptoms, and introduces a new spindle detection method.

Slow oscillations promote long range effective communication: the key for memory consolidation in a broken down network

The paper shows that slow oscillations during NREM sleep enhance long-range neural communication, which supports memory consolidation despite reduced overall connectivity.

Sigma Oscillations Protect or Reinstate Motor Memory Depending on their Temporal Coordination with Slow Waves

The paper shows that auditory TMR during sleep enhances motor memory by modulating slow wave-sigma oscillation coupling depending on timing.

A non-lemniscal thalamic interface connecting alerting sensory cues to internal states in mice

This paper identifies the medial sector of the auditory thalamus (ATm) as an interface that transforms alerting environmental cues into internal arousal and emotional state changes in mice.

Waveform detection by deep learning reveals multi-area spindles that are selectively modulated by memory load

The paper uses deep learning to detect sleep spindles across multiple brain areas and finds they are widespread and modulated by memory load.

Somatic genetics analysis of sleep in adult mice

This paper introduces a somatic genetics approach using AAV-based expression and knockout to study sleep in adult mice, identifying new sleep regulators and demonstrating its utility for essential or redundant genes.

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

This study examines how sleep deprivation affects cortical excitability, plasticity, and cognitive functions like learning and memory in humans.

Autonomic/Central Coupling during Daytime Sleep Differs between Older and Younger People

This study examines age-related differences in autonomic-central coupling during daytime sleep and its impact on working memory in older versus younger adults.

Timely sleep coupling: spindle-slow wave synchrony is linked to early amyloid-β burden and predicts memory decline

The paper examines the link between spindle-slow wave coupling during sleep and early amyloid-β burden, finding it associated with memory decline in midlife individuals.

INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

Human REM sleep controls neural excitability in support of memory formation

This study shows REM sleep recalibrates excitation/inhibition balance, predicting memory consolidation success in humans.

Sleep spindles track cortical learning patterns for memory consolidation

The paper shows that sleep spindles correlate with learning patterns and predict memory consolidation in humans.

Vigilance and behavioral state-dependent modulation of cortical neuronal activity throughout the sleep/wake cycle

The paper examines the activity patterns of specific inhibitory neurons in mice across sleep and wake states, revealing distinct firing dynamics in different behavioral contexts.

Weak representation of awake/sleep states by local field potentials in aged mice

This study shows that aged mice show reduced representation of awake/sleep states in local field potential correlations, which can be partially restored with environmental enrichment.

Urethane Anesthesia Exhibits Neurophysiological Correlates of Unconsciousness and is Distinct from Sleep

This study compares electroencephalographic signatures of urethane anesthesia and natural sleep-wake states in rats, finding distinct neurophysiological features in urethane that differentiate it from sleep.