Sleep and Wakefulness Research

Cueing motor memory reactivation during NREM sleep engenders learning-related changes in precuneus and sensorimotor structures

This study shows that reactivating motor memory during sleep increases precuneus activation and predicts long-term benefits, while also causing structural and functional changes in sensorimotor cortex.

The brain tunes to unfamiliar voices during sleeping

This study investigates how the sleeping brain responds to familiar and unfamiliar voices, finding that unfamiliar voices elicit stronger neural responses, particularly through K-complexes and oscillatory activity.

Targeted Memory Reactivation of Face-Name LearningDepends on Ample and Undisturbed Slow-Wave Sleep

This study shows that targeted memory reactivation during sleep improves face-name recall, with benefits linked to slow-wave sleep duration and reduced sleep disruption.

Non-REM sleep in major depressive disorder

This study analyzes non-REM sleep EEG features in MDD patients and finds subtle alterations linked to medication and memory consolidation.

Narcolepsy and the Dissociation of REM Sleep and Cataplexy through Ambient Temperature Manipulation

This study shows that REM sleep and cataplexy can be dissociated in Hcrt-KO mice through ambient temperature manipulation, revealing distinct neural circuit controls.

The adolescent pattern of sleep spindle development revealed by HD-EEG polysomnography

This study uses HD-EEG polysomnography to analyze sleep spindle development in adolescents, finding age-related changes in frequency, amplitude, duration, and density, with gender differences in the oldest age group.

Competitive dynamics underlie cognitive improvements during sleep.

The paper shows sleep involves competition between long-term and working memory processes, with a switch mechanism affecting cognitive performance.

LKB1 Is Physiologically Required for Sleep from Drosophila to the Mouse

This study shows LKB1 is required for sleep in both Drosophila and mice, with reduced sleep observed in Lkb1 mutants across species.

Sleep-learning Impairs Subsequent Awake-learning

This study shows that sleep-learning impairs subsequent awake-learning when the new information is congruent with sleep-formed associations, but not when it conflicts.

Localizing spontaneous memory reprocessing during human sleep

This study uses machine learning on MEG data to show localized memory reprocessing in hippocampus and neocortex during sleep.

Oscillatory population-level activity of dorsal raphe serotonergic neurons sculpts sleep structure

This study shows that population-level activity of dorsal raphe 5-HT neurons oscillates during NREM sleep, influencing EEG and EMG patterns, and suggests similar activity in humans.

Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in human and mice

The paper identifies dysfunction of the paraventricular hypothalamic nucleus (PVH) as a cause of hypersomnia in humans and mice through neural activity and behavioral studies.

Sleep spindle frequency: overnight dynamics, afternoon nap effects, and possible circadian modulation

The paper analyzes sleep spindle frequency dynamics across overnight sleep and naps to assess circadian modulation and age-related changes.

Bedtime to the brain: How infants sleep habits intertwine with sleep neurophysiology

This paper links infants' sleep habits measured by actimetry with neurophysiological features from EEG in 6-month-olds, showing associations between sleep patterns and brain activity metrics.

Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla

This study shows that GABAergic neurons in the dorsomedial medulla promote REM sleep initiation and maintenance through projections to raphe nuclei and synchronization with infraslow oscillations during NREMs.

Natural age-related sleep-wake alterations onset prematurely in the Tg2576 mouse model of Alzheimer disease

This study shows that Tg2576 mice exhibit early sleep-wake alterations resembling aged controls before plaque formation, suggesting premature sleep deterioration in AD models.

Noradrenergic control of non-REM sleep substates

The paper shows that noradrenaline fluctuations during non-REM sleep influence sleep spindle clustering and heart rate variations through thalamic circuits.

Nitric oxide synthase neurons in the preoptic hypothalamus are sleep-active and contribute to regulating NREM and REM sleep and lowering body temperature.

The paper identifies NOS1 neurons in the preoptic hypothalamus as sleep-active and shows they regulate NREM and REM sleep and body temperature.

Realization of phosphorylation hypothesis of sleep by mammalian CaMKIIβ

This study shows that CaMKIIβ phosphorylation regulates sleep duration and steps in mammals by modulating kinase activity in excitatory neurons.

Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

This paper demonstrates that phase-targeted closed-loop auditory stimulation in rats modulates sleep slow waves and improves motor learning performance.

Reactivating Memories from a Mathematical Task over a Period of Sleep

This study tests if memory reactivation during sleep improves multiplication learning but finds no effect on response time or accuracy.

Slow oscillations provide the spatio-temporal framework for long-range neural communication during sleep

The paper investigates slow oscillations during sleep, showing they enable long-range neural communication and support memory consolidation.

Sleeping While Awake: The Intrusion of Neural Activity Associated with Sleep Onset in the Awake Human Brain

The paper identifies sleep-onset neural activity intruding into awake human brain activity during cognitive tasks, showing spatial and temporal patterns linked to reduced arousal.

Light-regulated SIK1 remodels the synaptic phosphoproteome to induce sleep

This study shows that SIK1 activity modulates synaptic phosphoproteome to induce sleep independently of sleep pressure, revealing a causal mechanism for sleep regulation.

Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons

The paper shows that narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons, not their destruction, using QRFP as a marker and methylation analysis.

Local coupling between sleep spindles and slow oscillations supports the stabilization of motor memories

This paper investigates the role of sleep spindle-slow oscillation coupling in motor memory consolidation and finds that coupled spindles predict long-term memory retention.

Role of hypocretin in the medial preoptic area in the regulation of sleep, maternal behavior and body temperature of lactating rats.

Interrelations between delta waves, spindles and slow oscillations in human NREM sleep and their functional role in memory

This study investigates delta waves, spindles, and slow oscillations in human NREM sleep and their role in memory formation in older adults, finding that the ratio of SO- to delta-nested spindles predicts memory ability.

Estradiol Influences Adenosinergic Signaling and NREM Sleep Need in Adult Female Rats

This study investigates how estradiol affects adenosinergic signaling and NREM sleep need in adult female rats, finding that estradiol increases extracellular adenosine and blocks A2A receptor effects in the MnPO.

Sleeping at the Switch

The paper identifies two types of slow waves in human sleep, slow switchers and fast switchers, and shows aging is associated with reduced connectivity and faster dissipation of sleep pressure.