Veterinary Oncology Research

Survival time and prognostic factors in dogs diagnosed with haemangiosarcoma in UK first opinion practice

This study examines survival times and prognostic factors in dogs with haemangiosarcoma in UK first-opinion practice, finding short median survival times and identifying key predictors of outcome.

Prognostic significance of Ki-67, BAX, Caspase-3, and VEGF expression in feline intestinal lymphoma

This study evaluates the prognostic value of Ki-67, BAX, caspase-3, and VEGF-A in feline intestinal lymphoma, finding associations between biomarker expression and survival outcomes.

Genomic analyses identify 15 susceptibility loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally-occurring canine model of gastric cancer

The paper identifies 15 genetic loci associated with gastric cancer in dogs, highlighting HDAC2, SOX2-OT, and IGF2BP2 as potential risk factors.

Frequency and Characterization of Rare Histologic Subtypes in Canine Invasive Urothelial Carcinoma

This study identifies higher frequencies of specific histologic subtypes and divergent differentiation in canine urothelial carcinoma compared to previous reports, suggesting dogs as a model for human sarcomatoid UC.

Horizontal transfer of nuclear DNA in transmissible cancer

The paper detects a single instance of host-to-tumour horizontal DNA transfer in canine transmissible venereal tumour, showing a 15-megabase genetic element from a dog with Middle Eastern ancestry.

Gene expression in soft-shell clam (Mya arenaria) transmissible cancer reveals survival mechanisms during host infection and seawater transfer

Comparative multi-omics analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas

This study compares molecular profiles of canine and human thyroid carcinomas, identifying distinct genetic and transcriptomic features and potential biomarkers for prognosis and treatment.

Differentially expressed growth factors and cytokines drive phenotypic changes in transmissible cancers

This study identifies cytokines and growth factors driving phenotypic plasticity in transmissible Tasmanian devil cancers and suggests therapeutic targets.

Whole Genome 3D Blood Biopsy Profiling of Canine Cancers: Development and Validation of EpiSwitch Multi-Choice Array-Based Diagnostic Test.

This paper develops and validates a 3D genomic blood test for diagnosing multiple canine cancers with high sensitivity and specificity.

Study Design and Interim Analysis of the Cancer Lifetime Assessment Screening Study in Canines (CLASSiC): The First Prospective Cancer Screening Study in Dogs Using Next-Generation Sequencing-Based Liquid Biopsy

The paper presents an interim analysis of a canine cancer screening study using NGS-based liquid biopsy, showing increased preclinical cancer detection with OncoK9(R) testing.

Next-generation sequencing-based liquid biopsy can be used for detection of residual disease and cancer recurrence monitoring in dogs

This study evaluates a next-generation sequencing-based liquid biopsy test for detecting residual disease and monitoring cancer recurrence in dogs, finding it can identify recurrence earlier than clinical assessment.

Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma

The paper identifies common genomic alterations in canine splenic hemangiosarcoma and links them to clinical outcomes and treatment responses.

Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds

The paper identifies germline regulatory variants associated with histiocytic sarcoma in flat-coated retrievers using a multi-omics approach and GWAS.

A comparative meta and in silico analysis of differentially expressed genes and proteins in canine and human bladder cancer

This paper compares differentially expressed genes and proteins in canine and human bladder cancer through meta-analysis and cross-validation of transcriptome data.

Molecular Parallelisms and Divergences Between Human and Canine Mammary Cancer

This study compares genomic and transcriptomic differences between human and canine mammary cancers, revealing both similarities and divergences in mutation patterns and selective pressures.

Feasibility and promise of circulating tumor DNA analysis in dogs with naturally-occurring sarcoma.

This study demonstrates the feasibility of ctDNA analysis in dogs with hemangiosarcoma using shallow whole genome sequencing, showing higher ctDNA fractions in malignant tumors compared to benign ones.

Consensus-based somatic variant-calling method correlates FBXW7 mutations with poor prognosis in canine B-cell lymphoma

The paper identifies FBXW7 mutations as a prognostic marker in canine B-cell lymphoma using exome sequencing and clinical data.

The tree that hides the forest: identification of common predisposing loci in several hematopoietic cancers and several dog breeds.

This study identifies common genetic risk loci for hematopoietic cancers in dogs and humans by combining GWAS, sequencing, and imputation across breeds and cancers.

Genomic analysis reveals shared genes and pathways in human and canine angiosarcoma

The paper compares genomic features of canine and human angiosarcoma, finding shared genes and pathways, suggesting dogs as a valuable model for studying this cancer.

Tasman-PCR: A genetic diagnostic assay for Tasmanian devil facial tumour diseases

The paper introduces Tasman-PCR, a PCR-based assay that distinguishes between DFT1 and DFT2 in Tasmanian devils with high sensitivity and specificity.