Veterinary Oncology Research

When Prognostic Compatibility Does Not Guarantee Transfer Utility in Event-Limited Cross-Species Survival Modeling

The paper evaluates cross-species survival modeling in osteosarcoma, finding that prognostic compatibility does not ensure safe transfer utility due to negative transfer and model-selection bias.

Primary tumor transcriptomic signature is associated with locoregional dissemination in canine mammary carcinoma

The paper develops a transcriptomic risk score to predict locoregional dissemination in canine mammary carcinoma using gene set analysis.

Longitudinal single-cell and spatial transcriptomics reveals intratumor heterogeneity, therapeutic response, and comparative value of canine marginal zone lymphoma

A 16-colour spectral flow cytometry panel to characterise T cell immunophenotypes in canine oral melanoma

The paper develops a 16-color spectral flow cytometry panel to analyze T cell immunophenotypes in canine oral melanoma and identifies distinct immune features in the tumor microenvironment.

Convergent biology, divergent drivers: a cross-species comparison of human and canine invasive urothelial carcinoma

This study compares the biology and genetic drivers of human and canine invasive urothelial carcinoma, finding shared cellular organization but distinct mutations and platform effects in organoids.

Feline mammary carcinomas display evidence of stemness, epithelial-mesenchymal plasticity, and metastasis-associated M2-like macrophage infiltration

This study examines feline mammary carcinomas and finds they exhibit stemness, epithelial-mesenchymal plasticity, and M2-like macrophage infiltration, similar to human triple-negative breast cancer.

Cross-species Study of Canine and Human Peripheral Nerve Sheath Tumors: Clinical and Molecular Perspectives

This study compares canine and human peripheral nerve sheath tumors, finding that H3K27me3 loss and H3K27ac gain drive tumor progression in both species.

Sulfoquinovosylacylpropanediol monotherapy suppresses canine hemangiosarcoma patient-derived xenograft models with vascular remodeling

This study shows that SQAP reduces tumor growth in canine HSA PDX models by altering vascular and macrophage-related tumor microenvironment features, not through direct cytotoxicity.

A multi-modal transcriptomic atlas reveals the cellular and spatial landscape of canine gastric cancer

This study creates a transcriptomic atlas of canine gastric cancer using single-nucleus RNA-sequencing, bulk RNA-sequencing, and spatial transcriptomics, revealing molecular similarities to human disease.

Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients

This study evaluates an intratumoral B7H3:CD3 TCE in canine sarcoma patients, showing localized T-cell accumulation without systemic toxicity.

Stem Cell Divisions, Driver Mutations, and Carcinogenesis in Purebred Dogs

This paper reanalyzes dog cancer mortality data to suggest that single driver mutations may initiate cancer, with somatic mutation rates increasing with body weight and 56% of cancers linked to somatic cell divisions.

Multiomic profiling of human and canine soft-tissue sarcomas reveals extensive molecular homology across species and identifies clinically relevant subgroups

This study compares multiomic profiles of human and canine soft-tissue sarcomas, revealing molecular similarities and identifying clinically relevant subgroups.

Multi-omic Longitudinal Analysis of Canine Osteosarcoma Identifies Inter-Patient Heterogeneity and Immune Enrichment in Metastatic Lesions

This study analyzes multi-omic data from canine osteosarcoma to identify inter-patient heterogeneity and immune enrichment in metastatic lesions.

Satellite DNA fragility accompanies complex genome rearrangements and ecDNA oncogene amplification in canine osteosarcomas

This study identifies satellite DNA fragility and ecDNA oncogene amplification in canine osteosarcomas using long-read sequencing, revealing genomic instability mechanisms relevant to human cancer.

Harmonized nonhuman cancer database

The paper presents a harmonized nonhuman cancer database with tumors from 41,539 individuals across 825 species, revealing tissue-specific cancer incidence patterns.

The shared selection landscape of dog and human cancers

This study compares genomic features of dog and human cancers across multiple types, finding widespread shared mutational signatures and genes, suggesting dogs as valuable models for precision oncology.

The Cost of Fame: Strong Biases in Comparative Oncology of Captive Species

This study shows that cancer risk trends in captive species are biased by species popularity, altering previously reported associations between tumour prevalence and biological factors.

Lymph-node transcriptomics define prognostic immune states in mucosal melanoma and reveal IBA1 as a practical biomarker for improved prognosis

This study identifies two prognostic lymph node subgroups in canine oral mucosal melanoma using transcriptomics, with IBA1 expression linked to improved survival.

Epithelial-Mesenchymal Plasticity is Associated with Immunosuppressive Features in Canine Mammary Carcinomas

This study shows that epithelial-mesenchymal plasticity in canine mammary carcinomas is linked to immunosuppressive features and recruitment of immunosuppressive cells.

The caninized anti-canine PD-1 monoclonal antibody in canine oral malignant melanoma: Efficacy and exploratory biomarker analysis

This study evaluates a caninized anti-PD-1 antibody in canine oral malignant melanoma, finding associations between baseline inflammatory markers and MSI status with treatment outcomes.

Response to "No evidence that transmissible cancer has shifted from emergence to endemism in Tasmanian devils"

The paper rebuts a critique by showing that re-analyzed data supports the original findings that the transmissible cancer in Tasmanian devils has transitioned to endemism.

Prognostic significance of Ki-67, BAX, Caspase-3, and VEGF expression in feline intestinal lymphoma

This study evaluates the prognostic value of Ki-67, BAX, caspase-3, and VEGF-A in feline intestinal lymphoma, finding associations between biomarker expression and survival outcomes.

Frequency and Characterization of Rare Histologic Subtypes in Canine Invasive Urothelial Carcinoma

This study identifies higher frequencies of specific histologic subtypes and divergent differentiation in canine urothelial carcinoma compared to previous reports, suggesting dogs as a model for human sarcomatoid UC.

Comparative multi-omics analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas

This study compares molecular profiles of canine and human thyroid carcinomas, identifying distinct genetic and transcriptomic features and potential biomarkers for prognosis and treatment.

Whole Genome 3D Blood Biopsy Profiling of Canine Cancers: Development and Validation of EpiSwitch Multi-Choice Array-Based Diagnostic Test.

This paper develops and validates a 3D genomic blood test for diagnosing multiple canine cancers with high sensitivity and specificity.

Study Design and Interim Analysis of the Cancer Lifetime Assessment Screening Study in Canines (CLASSiC): The First Prospective Cancer Screening Study in Dogs Using Next-Generation Sequencing-Based Liquid Biopsy

The paper presents an interim analysis of a canine cancer screening study using NGS-based liquid biopsy, showing increased preclinical cancer detection with OncoK9(R) testing.

Molecular Parallelisms and Divergences Between Human and Canine Mammary Cancer

This study compares genomic and transcriptomic differences between human and canine mammary cancers, revealing both similarities and divergences in mutation patterns and selective pressures.

Feasibility and promise of circulating tumor DNA analysis in dogs with naturally-occurring sarcoma.

This study demonstrates the feasibility of ctDNA analysis in dogs with hemangiosarcoma using shallow whole genome sequencing, showing higher ctDNA fractions in malignant tumors compared to benign ones.

Consensus-based somatic variant-calling method correlates FBXW7 mutations with poor prognosis in canine B-cell lymphoma

The paper identifies FBXW7 mutations as a prognostic marker in canine B-cell lymphoma using exome sequencing and clinical data.

The tree that hides the forest: identification of common predisposing loci in several hematopoietic cancers and several dog breeds.

This study identifies common genetic risk loci for hematopoietic cancers in dogs and humans by combining GWAS, sequencing, and imputation across breeds and cancers.