Veterinary Oncology Research

Identification of Expressed Endogenous Retroviral Element Associated Long Terminal Repeats in Devil Facial Tumour Cells

The paper identifies expressed endogenous retroviral element long terminal repeats (ERV LTRs) in devil facial tumour cells and validates them as potential vaccine targets.

When Prognostic Compatibility Does Not Guarantee Transfer Utility in Event-Limited Cross-Species Survival Modeling

The paper evaluates cross-species survival modeling in osteosarcoma, finding that prognostic compatibility does not ensure safe transfer utility due to negative transfer and model-selection bias.

Primary tumor transcriptomic signature is associated with locoregional dissemination in canine mammary carcinoma

The paper develops a transcriptomic risk score to predict locoregional dissemination in canine mammary carcinoma using gene set analysis.

Longitudinal single-cell and spatial transcriptomics reveals intratumor heterogeneity, therapeutic response, and comparative value of canine marginal zone lymphoma

A 16-colour spectral flow cytometry panel to characterise T cell immunophenotypes in canine oral melanoma

The paper develops a 16-color spectral flow cytometry panel to analyze T cell immunophenotypes in canine oral melanoma and identifies distinct immune features in the tumor microenvironment.

Convergent biology, divergent drivers: a cross-species comparison of human and canine invasive urothelial carcinoma

This study compares the biology and genetic drivers of human and canine invasive urothelial carcinoma, finding shared cellular organization but distinct mutations and platform effects in organoids.

Feline mammary carcinomas display evidence of stemness, epithelial-mesenchymal plasticity, and metastasis-associated M2-like macrophage infiltration

This study examines feline mammary carcinomas and finds they exhibit stemness, epithelial-mesenchymal plasticity, and M2-like macrophage infiltration, similar to human triple-negative breast cancer.

Cross-species Study of Canine and Human Peripheral Nerve Sheath Tumors: Clinical and Molecular Perspectives

This study compares canine and human peripheral nerve sheath tumors, finding that H3K27me3 loss and H3K27ac gain drive tumor progression in both species.

Neuroepithelial reprogramming and ERBB vulnerability in canine acanthomatous ameloblastoma

This study uses single-nucleus RNA-seq to identify unique neuroepithelial features in canine acanthomatous ameloblastoma, revealing ERBB4 as a therapeutic target.

Sulfoquinovosylacylpropanediol monotherapy suppresses canine hemangiosarcoma patient-derived xenograft models with vascular remodeling

This study shows that SQAP reduces tumor growth in canine HSA PDX models by altering vascular and macrophage-related tumor microenvironment features, not through direct cytotoxicity.

A multi-modal transcriptomic atlas reveals the cellular and spatial landscape of canine gastric cancer

This study creates a transcriptomic atlas of canine gastric cancer using single-nucleus RNA-sequencing, bulk RNA-sequencing, and spatial transcriptomics, revealing molecular similarities to human disease.

Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients

This study evaluates an intratumoral B7H3:CD3 TCE in canine sarcoma patients, showing localized T-cell accumulation without systemic toxicity.

Stem Cell Divisions, Driver Mutations, and Carcinogenesis in Purebred Dogs

This paper reanalyzes dog cancer mortality data to suggest that single driver mutations may initiate cancer, with somatic mutation rates increasing with body weight and 56% of cancers linked to somatic cell divisions.

Multiomic profiling of human and canine soft-tissue sarcomas reveals extensive molecular homology across species and identifies clinically relevant subgroups

This study compares multiomic profiles of human and canine soft-tissue sarcomas, revealing molecular similarities and identifying clinically relevant subgroups.

Metabolic Pathways Fuelling Devil Facial Tumour Disease

This study compares the metabolic profiles of two transmissible cancers in Tasmanian devils, finding DFT2 has higher glycolytic activity and less metabolic flexibility than DFT1.

Multi-omic Longitudinal Analysis of Canine Osteosarcoma Identifies Inter-Patient Heterogeneity and Immune Enrichment in Metastatic Lesions

This study analyzes multi-omic data from canine osteosarcoma to identify inter-patient heterogeneity and immune enrichment in metastatic lesions.

When Cells Rebel: a comparative genomics investigation into marsupial cancer susceptibility

This study investigates genetic factors contributing to high cancer susceptibility in marsupials by comparing genome expansions of oncogenes between dasyurid and non-dasyurid species.

Detection of vasculogenic mimicry in equine ocular, oronasal, and genital squamous cell carcinoma

The paper identifies vasculogenic mimicry in equine squamous cell carcinomas using histopathological and immunohistochemical analyses.

Satellite DNA fragility accompanies complex genome rearrangements and ecDNA oncogene amplification in canine osteosarcomas

This study identifies satellite DNA fragility and ecDNA oncogene amplification in canine osteosarcomas using long-read sequencing, revealing genomic instability mechanisms relevant to human cancer.

Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology

This paper argues for integrating phylogenetic comparative methods into evolutionary medicine, using comparative oncology to show how these methods can reveal evolutionary patterns in disease traits.

Harmonized nonhuman cancer database

The paper presents a harmonized nonhuman cancer database with tumors from 41,539 individuals across 825 species, revealing tissue-specific cancer incidence patterns.

The shared selection landscape of dog and human cancers

This study compares genomic features of dog and human cancers across multiple types, finding widespread shared mutational signatures and genes, suggesting dogs as valuable models for precision oncology.

The Cost of Fame: Strong Biases in Comparative Oncology of Captive Species

This study shows that cancer risk trends in captive species are biased by species popularity, altering previously reported associations between tumour prevalence and biological factors.

Lymph-node transcriptomics define prognostic immune states in mucosal melanoma and reveal IBA1 as a practical biomarker for improved prognosis

This study identifies two prognostic lymph node subgroups in canine oral mucosal melanoma using transcriptomics, with IBA1 expression linked to improved survival.

Epithelial-Mesenchymal Plasticity is Associated with Immunosuppressive Features in Canine Mammary Carcinomas

This study shows that epithelial-mesenchymal plasticity in canine mammary carcinomas is linked to immunosuppressive features and recruitment of immunosuppressive cells.

The caninized anti-canine PD-1 monoclonal antibody in canine oral malignant melanoma: Efficacy and exploratory biomarker analysis

This study evaluates a caninized anti-PD-1 antibody in canine oral malignant melanoma, finding associations between baseline inflammatory markers and MSI status with treatment outcomes.

In vitro detection of canine anti-human antibodies following intratumoral injection of the hu14.18-IL2 immunocytokine in spontaneous canine melanoma

The paper detects canine anti-human antibodies (CAHA) in dogs treated with hu14.18-IL2 immunocytokine, showing increased levels and binding inhibition post-treatment.

Barking Up the Right Tree: Immune Checkpoint Signatures of Human and Dog Cancers

The paper compares immune checkpoint expression in canine and human cancers, identifying similarities and differences that suggest potential for immunotherapy models.

Capacity for compensatory cyclin D2 response confers trametinib resistance in canine mucosal melanoma

This study identifies a compensatory cyclin D2 response as a mechanism conferring trametinib resistance in canine mucosal melanoma.

Response to "No evidence that transmissible cancer has shifted from emergence to endemism in Tasmanian devils"

The paper rebuts a critique by showing that re-analyzed data supports the original findings that the transmissible cancer in Tasmanian devils has transitioned to endemism.