Ion Channels and Receptors

The paper identifies sex-dependent differences in transcriptomic profiles of lingual sensory neurons in naive and tongue-tumor bearing mice.

The paper identifies distinct subsets of DRG neurons innervating the distal colon with different mechanosensitivity thresholds, showing their role in physiological and pathological responses to colon distension.

This study identifies Orai-mediated Ca2+ entry as a key regulator of gene expression in flight-promoting dopaminergic neurons, essential for their functional maturation and flight behavior.

The paper identifies TRPM4 channels as key mediators of cholinergic modulation of firing rate adaptation in CA1 pyramidal neurons during depolarizing ramps.

This paper shows that the voltage-gated sodium channel Para localizes to dendrites and axons in Drosophila chordotonal neurons, suggesting dendritic spike initiation zones and roles in mechanotransduction.

This study investigates Ca2+ signaling in capillary pericytes, finding that Orai-mediated store-operated Ca2+ entry mediates microdomain signals and amplifies Gq-coupled Ca2+ elevations.

The paper identifies multiple calcium-dependent mechanisms regulating CMK-1 subcellular localization in C. elegans thermal nociceptors, showing how phosphorylation and CaM binding interact to control nuclear entry and export.

The paper identifies TRPV1+/MrgprA3+ prurioceptors and Piezo2 channel signaling as drivers of pruritogen-induced alloknesis.

The paper shows that inflammatory mediators activate TRPV1 and TRPA1 nociceptors, leading to cold pain in mice that depends on TRPM8 and GFRalpha3, with sex-specific effects.

This study shows that loss of Rtnl1 in Drosophila disrupts presynaptic ER organization and causes defects in Ca2+ dynamics and neurotransmission.

This study identifies cortical neurons in mice that respond to cooling and warming, showing cool representation in primary somatosensory cortex and both cool and warm in posterior insular cortex.

The paper identifies five functionally distinct mechanosensory neuron subsets in the mouse tongue using in vivo calcium imaging and clustering analysis of their response profiles to mechanical stimuli.

This study investigates the role of TRPV4 in mechanically regulated prenatal skeletal development, showing its importance in joint cartilage growth and shape through mechanotransduction.

The paper uses patch-clamp recordings to study mechanotransduction in duck Meissner corpuscle afferents, showing fast kinetics of mechanically activated current and rapidly adapting firing.

The paper evaluates six commercial antibodies for detecting TRPM8 using western blot, immunocytochemistry, and immunohistochemistry, finding two broadly effective and four with limited utility.

The paper introduces a non-contact cooling stimulator to study cold sensation without mechanical contact, finding cold detection thresholds in humans.

This study shows capsaicin reduces presynaptic CaV2.2 expression in DRG neurons via Rab11a-dependent endocytosis, impairing neurotransmission.

The paper investigates the distribution of TRP channels in human oral tissues to understand their role in environmental sensing.

This study investigates whether TMEM150c forms a mechanosensitive ion channel or is required for mechanosensitivity in sensory neurons, finding no evidence to support these claims.

The paper investigates the roles of PEZO-1 and TRP-4 mechanosensors in C. elegans mating behavior, showing their involvement in multiple mating steps and mechanosensory functions.

This study identifies modality-specific roles for metabotropic GABAergic signaling and calcium-induced calcium release in regulating cold nociception in Drosophila CIII neurons.

This study identifies Piezo1 as the major mechanotransducer in keratinocytes for detecting mechanical stimuli and transmitting tactile information to sensory neurons.

The paper shows TACAN inhibits Piezo2 channel activity in DRG neurons without affecting Piezo1 or TREK1 currents.

This study identifies a role for peripheral kappa opioid receptors in driving cold hypersensitivity through modulation of TRPA1 channels in mice.

This study shows that Gq-coupled receptor activation induces oscillatory calcium signaling in hOPCs, which blocks differentiation and promotes proliferation through SOCE, suggesting potential therapeutic targets for myelin repair.

This paper demonstrates that expressing human TRPA1 channels in neurons allows ultrasound to control neural activity in the intact mammalian brain.

The paper shows TRPV1-lineage fibers communicate with parabrachial taste neurons, integrating somatosensory and gustatory signals in mice.

This study identifies distinct pezo-1 isoforms in C. elegans with tissue-specific expression and functional roles in food intake regulation.

The paper combines mechanosensitive current recordings with single-cell RNA sequencing in mouse DRG neurons to identify candidate genes for mechanosensory functions.

This study shows that RTX reduces nocifensive response in C. elegans to noxious heat and identifies Wnt signaling as a pathway involved.