Ocular Oncology and Treatments

BAP1 loss and PRAME expression converge to remodel the tumor-immune ecosystem during uveal melanoma progression

The paper profiles single-cell data from uveal melanoma to show BAP1 loss and PRAME expression drive convergent immunoregulatory changes and immune resistance.

Topotecan Syndergizes with SP141 in the Management of Uveal Melanoma

This study investigates the synergistic effects of topotecan and SP141 in 92-1 uveal melanoma cells, showing significant growth inhibition and apoptosis.

Uveal and cutaneous melanoma share a common mutation with distinct prognostic implications: A bioinformatic study

This study identifies two shared genetic variants between uveal and cutaneous melanoma and suggests IRF4 as a common prognostic biomarker.

Doxycycline Modulates Uveal-Melanoma-Associated Marker Expression in BAP1-Repressed Human Ocular Organoids

This study tests doxycycline's effect on uveal melanoma in a human ocular organoid model, finding it inhibits growth, angiogenesis, and oxidative phosphorylation in BAP1-repressed cells.

LINE-1 transposon derepression and epigenetic remodeling in Retinoblastoma

This study shows increased LINE-1 expression and epigenetic remodeling in retinoblastoma, linking transposon activation to tumor biology.

A functional genomics screen identifies novel drivers of FR900359 resistance in uveal melanoma cells

This study identifies genes driving resistance to FR900359 in uveal melanoma cells through functional genomics screening and experimental validation.

A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma

The paper identifies E2F transcription factors as potential druggable targets in uveal melanoma by analyzing SOX10's role and its downstream effects.

A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma

This paper develops a genetically engineered mouse model of uveal melanoma that recapitulates human disease progression and immune microenvironment features, revealing phenotypic plasticity and cooperative genetic drivers.

GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases

This study identifies GDF15 as a driver of uveal melanoma liver metastasis by reprogramming hepatic stellate cells to promote angiogenesis and matrix deposition.

Novel biomarkers in mutation-specific gene profiles highlight the involvement of COL9A3 in cancer cell plasticity in uveal melanoma

The paper identifies COL9A3 as a novel high-risk biomarker in uveal melanoma associated with cell plasticity and is most prevalent in BAP1mut tumors.

Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in BAP1mut uveal melanoma

This study investigates the role of transcription factors FOXD1 and RBFOX2 in BAP1mut uveal melanoma progression using knock-out and overexpression models, finding they influence tumor growth and dissemination.

UHRF1 is critical for tumor-promoting inflammation and tumorigenesis in retinoblastoma

This study shows that UHRF1 is essential for retinoblastoma progression by promoting oncogenic transcription, chromatin accessibility, and immune microenvironment shaping, but not tumor initiation.

Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell death

This study shows that GNAQ/11 mutations in uveal melanoma alter IP3 receptor expression, protecting cells from calcium-driven death while promoting proliferation.

Genome-wide investigation of rare germline copy-number variants in retinoblastoma

The paper identifies rare germline copy-number variants associated with retinoblastoma risk outside the RB1 gene using whole-genome sequencing and statistical analysis.

Examination of INPP5A in uveal melanoma uncovers novel calcium transients

This study investigates INPP5A's role in uveal melanoma by analyzing calcium transients and shows that INPP5A inhibition alters calcium oscillations dependent on Gq/11 activity.

Molecular Genetic Analysis of RB1 gene among Sudanese children with Retinoblastoma

This study analyzes RB1 gene mutations in Sudanese retinoblastoma patients, finding no exon 18 mutations but identifying potential deleterious SNPs globally.