Intracerebral and Subarachnoid Hemorrhage Research

Translational validation of shotgun proteomics findings in cerebrospinal fluid of sporadic cerebral amyloid angiopathy patients

The paper validates potential biomarkers for sporadic cerebral amyloid angiopathy in human CSF, finding no significant differences in CTSB and CTSS levels but a decrease in HEXA activity.

Prominent elevation of extracellular matrix molecules in intracerebral hemorrhage

This study identifies elevated extracellular matrix molecules, particularly neurocan, in murine and human intracerebral hemorrhage, which inhibit oligodendrocyte precursor cell function and may impair repair.

Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhage

The paper performs deep resequencing of the 1q22 locus in non-lobar ICH cases and controls to identify causal variants and mechanisms.

Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

This study shows that neural stem cells reduce BBB permeability and brain edema after ICH in rats by inhibiting MAPK pathways.

A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage

This paper develops a genomic risk score for intracerebral hemorrhage using genome-wide association data and validates its predictive power in multiple cohorts.

rtPA Directly Protects Neurons After Intracerebral Hemorrhage through PI3K/AKT/mTOR Pathway

The paper investigates the neuroprotective effects of rtPA after ICH, showing it reduces apoptosis and autophagy via the PI3K/AKT/mTOR pathway.

Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage.

This study shows haptoglobin can protect neurons from sub-lethal haemoglobin-induced damage in an in vitro model of subarachnoid haemorrhage by reducing Hb concentrations without impairing neuronal function.

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhage

This study identifies a biphasic inflammatory response after intracerebral hemorrhage, with an early MyD88-TLR4-dependent activation of the choroid plexus preceding secondary inflammation and leukocyte infiltration.

Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage

This study shows that the pentapeptide CN-105 improves outcomes in multiple translational intracerebral hemorrhage models across different species, sexes, and ages.

Combining Attention-based Multiple Instance Learning and Gaussian Processes for CT Hemorrhage Detection

This paper proposes an attention-based multiple instance learning approach for CT hemorrhage detection using scan-level labels, achieving better performance than methods relying on slice-level annotations.

Piezo1 potentially mediates inflammation in balloon-inflated rat brain and its bidirectional mechanosensitivity

This study shows that Piezo1 mediates neuroinflammation in a rat model of hematoma compression, with its expression and inflammatory response affected by balloon deflation time.

Inhibitory effects of Akt on neuronal FoxO4 activation after subarachnoid hemorrhage in vivo and in vitro

This study investigates the role of Akt in inhibiting FoxO4 activation following subarachnoid hemorrhage in both in vivo and in vitro models.

The neutrophil enzyme myeloperoxidase directly modulates neuronal response after subarachnoid hemorrhage, a sterile injury model

This study shows that myeloperoxidase from neutrophils in the meninges modulates neuronal function after subarachnoid hemorrhage, leading to cognitive deficits.

Deep structural brain lesions associated with consciousness impairment early after haemorrhagic stroke

The paper uses MRI and machine learning to predict consciousness recovery and functional outcomes after haemorrhagic stroke by analyzing deep brain lesions.

Aspirin treatment does not increase microhemorrhage size in young or aged mice

This study investigates whether aspirin affects microhemorrhage size in young and aged mice, finding no significant difference compared to controls.