Intracerebral and Subarachnoid Hemorrhage Research

Serpin A3 is Increased in Cerebral Amyloid Angiopathy and ARIA

The paper investigates Serpin A3 expression in cerebral amyloid angiopathy and Alzheimer's disease using single-nucleus transcriptomics and microscopy, finding increased Serpin A3 in affected tissues.

APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

Integration of Neuroimaging and Histopathology in a Squirrel Monkey Model of Spontaneous Cerebral Amyloid Angiopathy and Amyloid-Related Imaging Abnormalities

This study uses MRI and histopathology in squirrel monkeys to link R2* changes with CAA severity and ARIA-related tissue injury, supporting early detection and treatment strategies.

Semaphorin 3G (SEMA3G) is a highly selective marker of cerebral amyloid angiopathy

The paper identifies SEMA3G as a specific marker for cerebral amyloid angiopathy (CAA) through analysis of human brain tissue and demonstrates its interaction with specific amyloid beta variants.

Linoleic Acid-Lyso PG Axis promoting lipid droplet-mitochondria tethering by stabilizing Noncanonically Mitochondrial PPAR β/δ to Ameliorate Microglial Dysfunction in subarachnoid hemorrhage

This study identifies a lipid signaling pathway involving LA and LPG(16:0) that stabilizes PPAR{delta} on mitochondria, improving microglial function and reducing brain injury after SAH.

Recombinant GDF11 Improves Neurological Recovery in Models of Hemorrhagic Stroke and Traumatic Brain Injury

This study shows that recombinant GDF11 improves neurological recovery in mouse models of hemorrhagic stroke and traumatic brain injury by enhancing functional and structural outcomes.

Mononuclear myeloid cells mount an adaptive protective response to intracerebral haemorrhage by activation of NRF2

The paper identifies NRF2 activation in mononuclear myeloid cells as a protective response to intracerebral haemorrhage, showing its therapeutic potential through modulation of interferon pathways.

Using atorvastatin-induced vascular weakness to model brain haemorrhage in vascularised cerebral organoids

This study uses vascularised cerebral organoids treated with atorvastatin to model intracerebral haemorrhage and assess tissue injury and immune response.

Vascular dilation modulates brain haematoma expansion in larval zebrafish

This study shows that vascular dilation reduces haematoma size in zebrafish ICH models, suggesting haemodynamic regulation influences haemorrhage progression.

Multifunctional nanozyme therapy accelerates hematoma clearance and attenuates genome damage and senescence after intracerebral hemorrhage

This study evaluates a multifunctional nanozyme therapy for intracerebral hemorrhage, showing it accelerates hematoma clearance and reduces genome damage and senescence.

Hyperhomocysteinemia does not increase the risk of intracerebral hemorrhage in hypertensive mice

This study investigates whether hyperhomocysteinemia increases intracerebral hemorrhage risk in hypertensive mice, finding no significant difference between groups.

Dissociation of Diffusion and Perfusion Responses After Intracerebral Hemorrhage

This study examines the spatiotemporal relationship between microstructural injury and cerebral perfusion after intracerebral hemorrhage in mice, finding dissociation between diffusion and perfusion responses.

Vascular Microbleeds Without Brain Atrophy: A Microvascular Signature of Mid-Stage 5xFAD Pathology

The paper identifies microbleeds as a specific marker of amyloid-related vascular injury in 5xFAD mice, distinct from small-vessel disease.

Gut metabolite IPA alleviates white matter injury post-ICH by enhancing myelin debris phagocytosis via Stap1 inhibition

This study shows that gut metabolite IPA reduces white matter injury after ICH by enhancing microglia phagocytosis of myelin debris through Stap1 inhibition.

Biological age acceleration is more prevalent in men than in women at time of spontaneous intracerebral hemorrhage

The paper compares epigenetic age acceleration between men and women with spontaneous intracerebral hemorrhage, finding men show greater acceleration than women.

Single Cell RNA Sequencing and Spatial Profiling Identify Mechanisms of Neonatal Brain Hemorrhage Development and Resolution

The paper uses single-cell RNA sequencing and spatial profiling to identify signaling networks involved in neonatal brain hemorrhage development and resolution in mice.

Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic stroke

This paper introduces an adult rat organotypic brain slice culture model to study ECM remodelling in haemorrhagic stroke and shows increased ECM deposition and inflammation after blood exposure.

Longitudinal Imaging of Experimental Intracerebral Hemorrhage Pathology with Iodine-enhanced Micro-CT

This study uses iodine-enhanced micro-CT to track acute and chronic changes in experimental intracerebral hemorrhage, showing correlation with MRI for lesion volume and iron deposition.

Vitamin D attenuates TNF-α-mediated neurotoxicity and improves functional recovery in experimental intracerebral haemorrhage

This study shows vitamin D reduces TNF-α-induced neurotoxicity and improves recovery in experimental intracerebral hemorrhage.

The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol

ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

The cellular diversity of human cerebrospinal fluid following intraventricular hemorrhage revealed by single-nucleus RNA sequencing

This study uses single-nucleus RNA sequencing to analyze CSF leukocytes after IVH, identifying distinct immune cell states and signaling networks involved in inflammation.

Blocking CCR2+ Monocyte Infiltration Enhances Neurological Recovery after Subarachnoid Hemorrhage

This study shows that blocking CCR2+ monocyte infiltration improves neurological recovery after subarachnoid hemorrhage by reducing neuroinflammation and neuronal cell death.

Single-Cell Analysis of Microglia and Monocyte Dynamics Uncover Distinct TNF-a-driven Neuroimmune Signatures after Intracerebral Hemorrhage

The paper uses single-cell transcriptomics to study microglia and monocyte dynamics after ICH, finding TNF signaling drives early monocyte activation and is linked to better neurological outcomes.

Loss of spontaneous vasomotion precedes impaired cerebrovascular reactivity and microbleeds in a mouse model of cerebral amyloid angiopathy

Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to β-amyloid deposition and lysyl oxidase.

This study links β-amyloid deposition and lysyl oxidase to arteriolar degeneration and stiffness in cerebral amyloid angiopathy using post-mortem human brain tissue analysis.

Translational validation of shotgun proteomics findings in cerebrospinal fluid of sporadic cerebral amyloid angiopathy patients

The paper validates potential biomarkers for sporadic cerebral amyloid angiopathy in human CSF, finding no significant differences in CTSB and CTSS levels but a decrease in HEXA activity.

Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

This study shows that neural stem cells reduce BBB permeability and brain edema after ICH in rats by inhibiting MAPK pathways.

rtPA Directly Protects Neurons After Intracerebral Hemorrhage through PI3K/AKT/mTOR Pathway

The paper investigates the neuroprotective effects of rtPA after ICH, showing it reduces apoptosis and autophagy via the PI3K/AKT/mTOR pathway.

Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage.

This study shows haptoglobin can protect neurons from sub-lethal haemoglobin-induced damage in an in vitro model of subarachnoid haemorrhage by reducing Hb concentrations without impairing neuronal function.

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhage

This study identifies a biphasic inflammatory response after intracerebral hemorrhage, with an early MyD88-TLR4-dependent activation of the choroid plexus preceding secondary inflammation and leukocyte infiltration.