Psychedelics and Drug Studies

The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms

This paper proposes the oneirogen hypothesis, suggesting classical psychedelics induce hallucinations by shifting neural activity toward dream-like states, and validates this through simulations using a wake-sleep neural network model.

Psilocybin prevents habituation to familiar stimuli and preserves sensitivity to sound following repeated stimulation in mouse primary auditory cortex.

This study shows psilocybin prevents habituation of sound-evoked responses in mouse primary auditory cortex, maintaining responsiveness and thresholds after repeated stimulation.

Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing

Co-administration of midazolam and psilocybin: Differential effects on subjective quality versus memory of the psychedelic experience

This study investigates how midazolam affects memory and subjective experience of psilocybin, suggesting memory plays a role in its therapeutic effects.

LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Brain Organoids

This study uses proteomics to show LSD alters proteins involved in proteostasis, energy metabolism, and neuroplasticity in human brain organoids.

Psilocybin facilitates fear extinction: importance of dose, context, and serotonin receptors

This study investigates how psilocybin affects fear extinction in mice, finding that dose, context, and serotonin receptors are critical factors.

Breathwork-Induced Psychedelic Experiences Modulate Neural Dynamics

The paper investigates how breathwork-induced psychedelic experiences affect neural dynamics using EEG and subjective reporting.

Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits

This study shows that psychedelics reduce predictive processing by weakening top-down cortical feedback circuits, an effect observed in both humans and mice.

Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT

This study shows that DMT alters connectome harmonics, increasing their repertoire entropy and correlating with subjective experience intensity over time.

Activity of prefrontal cortex serotonin 2A receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug DOI in a sex-dependent manner

This study shows that activating prefrontal cortex 5-HT2AR neurons alone does not induce head-twitch responses in mice, but their inhibition prevents DOI-induced responses, with sex-dependent effects.

5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats

This study shows that 5-MeO-DMT induces sleep-like LFP patterns in awake rats' hippocampus and prefrontal cortex, independent of locomotion and theta power changes.

The selective 5-HT2A receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents

This paper shows that LPH-5, a selective 5-HT2A receptor agonist, produces antidepressant-like effects in rodent models, suggesting its potential as a new psychedelic-derived antidepressant.

A dual-receptor model of serotonergic psychedelics

This paper develops a computational model of cortical dynamics to explain the therapeutic effects of serotonergic psychedelics and proposes a hypothesis for their clinical success.

Dynamic Functional Hyperconnectivity after Psilocybin Intake is Primarily Associated with Oceanic Boundlessness

This study links psilocybin-induced brain dynamics with phenomenological changes, showing hyperconnectivity correlates with oceanic boundlessness.

Cultivation, chemistry, and genome of Psilocybe zapotecorum

This paper describes the cultivation, chemical profile, and genome of Psilocybe zapotecorum, revealing its psilocybin content and gene cluster structure.

The psychedelic, DOI, increases dopamine release in nucleus accumbens to predictable rewards and reward cues

This study shows that the psychedelic DOI increases dopamine signaling to reward cues but not distal cues, supporting error-driven learning mechanisms.

Robust Methods For Quantifying Neuronal Morphology And Molecular Signaling Reveal That Psychedelics Do Not Induce Neuroplasticity

This study challenges the idea that psychedelics induce neuroplasticity by showing they do not modulate TrkB or BDNF-TrkB signaling or cause dendritic growth in neuronal cultures.

Psilocybin induces dose-dependent changes in functional network organization in rat cortex

This study examines how psilocybin affects brain network organization in rats, finding dose-dependent changes in connectivity and phase-amplitude coupling.

Transient destabilization of whole brain dynamics induced by DMT

This paper models the transient brain state changes induced by DMT using a time-dependent whole-brain model and fMRI data, showing heightened reactivity in specific brain regions correlated with serotonin receptor density.

Neural geometrodynamics, complexity, and plasticity: a psychedelics perspective

The paper explores how psychedelics affect neural dynamics by flattening the neural landscape, increasing complexity, and promoting adaptability through changes in plasticity mechanisms across different timescales.

Psilocybin biphasically modulates cortical and behavioral activity in mice

This study investigates how psilocybin affects cortical and behavioral activity in mice, finding biphasic effects on neural responses and behavior.

High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin

This study uses zebrafish behavior tracking to show psilocybin increases rapid swimming and prevents stress-induced irregular swimming, suggesting stimulatory and anxiolytic effects.

Effects of external stimulation on psychedelic state neurodynamics

This study examines how external stimuli modulate brain entropy during a psychedelic experience, finding that eye closure enhances entropy changes and that video stimuli disrupt the relationship between brain activity and subjective experience.

Brain dynamics predictive of response to psilocybin for treatment-resistant depression

The paper identifies brain regions and networks predictive of response to psilocybin therapy for treatment-resistant depression using whole-brain modeling and dynamic sensitivity analysis.

Psychedelic Concentrations of Nitrous Oxide Reduce Functional Differentiation in Frontoparietal and Somatomotor Cortical Networks

This study shows nitrous oxide reduces functional differentiation in brain networks and correlates with psychedelic experiences.

Psilocybin prevents activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms.

This study shows psilocybin improves cognitive flexibility and body weight in female rats with activity-based anorexia, mediated by 5-HT1A and 5-HT2A receptor mechanisms.

The unique neural signature of your trip: Functional connectome fingerprints of subjective psilocybin experience

This paper uses brain-fingerprinting to show that psilocybin increases idiosyncratic functional connectivity in the default-mode network, which predicts subjective drug experiences.

Cellular rules underlying psychedelic control of prefrontal pyramidal neurons

This study shows that psychedelics suppress intrinsic excitability of prefrontal pyramidal neurons via M-current channels, independent of 5-HT2AR activation, and reduces working memory timespan.

Intravenous psilocybin administration attenuates mechanical hypersensitivity in a rat model of chronic pain

This study shows that a single intravenous dose of psilocybin reduces mechanical hypersensitivity in a rat model of chronic pain for 28 days but has limited effect on thermal hyperalgesia.

Harmonic decomposition of spacetime (HADES) framework characterises the spacetime hierarchy of the DMT brain state

HADES framework analyzes spacetime activity patterns in the brain, showing reduced low-frequency harmonic modes during DMT-induced states, indicating changes in functional hierarchy.