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This study characterizes MoPARP1, a DNA-dependent PARP in Magnaporthe oryzae, revealing its biochemical properties and mechanism of DNA interaction.

This study shows fluorescence imaging induces phospholipid oxidation, shifting miscibility boundaries and causing membrane phase separation in model systems.

This study uses ion mobility and mass spectrometry imaging to identify distinct ganglioside isomers in Niemann-Pick Disease, showing therapeutic effects of gene therapy on lipid localization.

This study investigates how EWSR1::FLI1 binds to nucleosomes and DNA motifs, revealing its pioneer factor properties and preference for GGAA repeats.

This study shows that MPIase is essential for the TAT pathway by demonstrating its role in TAT substrate translocation in Escherichia coli.

This study shows FluPep, an anti-influenza peptide, binds to heparan sulfate and sialic acid on cells, preventing viral infection, and engineered versions enhance its potency.

The paper improves fluorescence contrast in EV-enriched fractions using proximity labeling and AI-assisted cutoff selection, showing increased signal-to-background ratio and differential fluorescence in ILD samples.

The paper introduces an improved fluorescent protein indicator, ChlorON-1-PRO, for real-time imaging of chloride transport in cells.

This study shows that actin and AnkJ reciprocally regulate the catalytic activity of Ceg14 by remodeling its catalytic center.

This paper enhances Cas12a's trans-cleavage activity by fusing Sso7d, improving sensitivity and kinetics for nucleic-acid detection.

This study reveals the structural and biophysical mechanisms of YicC, a novel bacterial RNase, showing its RNA binding and cleavage mechanism involving Mg2+ ions and dimeric conformations.

This study determines the atomic structure of the human tRNA-ligase complex and reveals its assembly mechanism and functional implications.

The paper investigates the role of arginine at position 2 of angiotensin II and shows that its conversion to glutamic acid or proline via oxidant-mediated mechanisms alters cellular signaling responses.

This study designs a chimeric adenylyl cyclase (AC95) to investigate isoform-specific regulation, revealing structural insights and drug target possibilities.

This study shows that folic acid polyglutamylation activates MAP2K5 signaling to promote adipocyte lipid breakdown, revealing a novel role for folate in lipid homeostasis.

This study identifies conserved aromatic residues in FTO that recognize the mRNA 5' cap and enhance m6Am demethylation, providing structural insights into FTO's selectivity for m6Am over m6A.

This paper develops a workflow for high-resolution metal imaging in C. elegans using LA-ICP-TOF-MS, achieving 2-m spatial resolution with optimized embedding and ablation techniques.

The paper identifies PAL3 in Arabidopsis as a novel enzyme converting 3-carboxy-tyrosine into carboxy-p-coumaric acid, reclassifying it as a 3-carboxy-tyrosine ammonia lyase.

This paper shows that DELE1CTD binds to HRI's N-terminal region, displacing haem and activating HRI through competition for the haem-binding site.

The paper identifies TAAR1 agonists with antipsychotic-like effects through computational screening and experimental validation, showing improved potency and reduced side effects in a schizophrenia model.