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Estrogen Receptor Expression Changes After Puberty in the Porcine Anterior Cruciate Ligament

This study examines estrogen receptor expression changes in porcine ACLs before and after puberty, finding increased ER expression post-puberty and potential age-dependent hormonal responsiveness.

Electroporation-mediated delivery of protein biosensors for metabolic imaging in differentiated myotubes

The paper develops an electroporation method to deliver protein biosensors into differentiated myotubes for real-time metabolic imaging.

iPSCs-derived Bronchial Airways-On-Chip for Assessment of Cytokine Secretion triggered by Volatile Organic Compounds

The paper develops a Bronchial Airways-On-Chip system using iPSC-derived bronchial epithelium to assess cytokine secretion from low-dose, long-term exposure to benzene, showing accumulative effects and reversibility with Montelukast.

Bacteroidales on Harvesters: Baseline Prevalence and Abundance

The paper assesses fecal contamination on harvester surfaces using qPCR and develops a portable LAMP assay for rapid hygiene assessment.

Patient-specific "Physical Twin" artery-on-chip platform reveals complex flow-dependent VWF mechanobiology and guides personalized antithrombotic therapy

The paper develops a patient-specific artery-on-chip platform to study flow-dependent VWF mechanobiology and guide personalized antithrombotic therapy.

Direct Synthesis of Targeted Nanosized ICG J-aggregate for Photoacoustic Imaging

This paper develops a method to directly synthesize targeted nanoscale ICG J-aggregates for photoacoustic imaging, demonstrating their strong signal generation and functionalization potential.

Dual Ligand Cooperation at the Plasma Membrane Drives Transport of Engineered Small Extracellular Vesicles Across Brain Endothelial Cells

This study engineers small extracellular vesicles with dual ligand targeting to enhance their uptake and transport across brain endothelial cells, showing improved delivery to the brain choroid plexus.

ThermiQuant™ AquaStream: A portable instrument for quantitative colorimetric isothermal nucleic acid amplification reactions in paper and tube formats

ThermiQuant AquaStream is a portable device that enables real-time colorimetric LAMP assays in both microPADs and tubes with high sensitivity and precision.

Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing

This study investigates how increased medial collagen affects aortic resilience against mural delamination by analyzing pressure responses in human aortic specimens under different conditions.

Detecting visual deficits in retinal degeneration mice using photoacoustic tomography

The paper uses photoacoustic tomography to detect visual deficits in retinal degeneration mice by measuring visually evoked hemodynamic responses.

Smartphone Placement Recognition during Walking: Performance Determinants and Real-World Generalizability

This paper develops and validates a classifier to recognize smartphone placement during walking, showing improved accuracy when aggregating pocket placements and highlighting performance variability across conditions.

Open-source robotic chip-to-plate interface for high-throughput microfluidic generation of materials libraries

LMNOP-bot automates microfluidic material library generation, increasing throughput 50x and enabling precise, reproducible deposition into standard well plates.

Kinetic properties of optogenetic site-specific DNA recombination by LiCre-loxP

This paper characterizes the kinetic properties of the optogenetic LiCre-loxP system using in vitro and in vivo experiments, revealing temperature-dependent efficiency and a model for recombination synapse formation.

Dynamic Fluoroleucine PET Detects Impaired Cardiac Leucine Uptake Before Hypertensive Left Ventricular Hypertrophy Develops

This paper uses [18F]FLE-PET/CT to detect reduced cardiac leucine uptake in hypertensive rats before LVH develops, suggesting it as an early marker for cardiometabolic dysfunction.

Advanced Fabrication Protocol of an Elastic Porous Membrane for Organ-on-a-chip Applications

This paper presents a robust fabrication protocol for elastic porous PDMS membranes used in organ-on-a-chip systems, improving reproducibility and reducing failure rates.

Muscle-driven hand simulations emphasize the critical role of the extensor mechanism

The paper uses biomechanical simulations to study hand motion, finding that extensor muscle path modifications improve accuracy in tracking interphalangeal joints during American Sign Language gestures.

Engineering a 3D Lung Co-culture Platform to Model Epithelial-Fibroblast Interactions in Pulmonary Fibrosis

This paper develops a 3D lung co-culture model to simulate epithelial-fibroblast interactions in IPF, showing it captures key fibrotic processes like myofibroblast differentiation and collagen disorganization.

Characterizing in vivo degradation of electrospun biodegradable nanofibers by size-exclusion chromatography

This study quantifies the in vivo degradation of biodegradable nanofibers using size-exclusion chromatography, revealing material- and environment-dependent degradation patterns.

Reprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes

This study identifies chromatin stability as critical for preserving chondrocyte function during expansion and shows that Fludarabine maintains phenotype by stabilizing chromatin and reducing STAT1 activity.

Neutrophil migration in the lung is altered by alveolar collapse and stretch

This study shows that alveolar collapse increases neutrophil migration speed, which is modulated by mechanical and biochemical factors.