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Cell shapes decode molecular phenotypes in image-basedspatial proteomics

The paper analyzes how cell shape correlates with proteomic features across multiple cell lines using image-based spatial proteomics data.

In Vivo Rescue of Cardiomyopathy Through Cardiac Prime Editing

This study demonstrates the use of in vivo prime editing to correct a cardiomyopathy-causing mutation in a humanized mouse model, rescuing disease phenotypes.

HYPER-Net: Physics-Conditioned Self-Supervised Reconstruction for Fourier Light-Field Microscopy

HYPER-Net enables physics-conditioned self-supervised reconstruction for Fourier light-field microscopy, improving volumetric imaging across diverse biological contexts.

Cardiac oxidative stress monitoring enabled by hierarchical mechanical adaptation

This paper introduces E-cardiac, a biosensor that monitors oxidative stress in beating hearts with mechanical adaptation, distinguishing ischemia-reperfusion injury severity and detecting the ECG blind window.

Single injection of modified self-amplifying RNA encoding a CD19 bispecific T cell engager mediates long-term malignant B cell clearance

This study develops a modified self-amplifying RNA-based BiTE system that provides long-term B cell clearance with a single injection.

Membrane-Free Alveolus-on-a-Chip via Biodegradable Scaffold Recapitulates Interstitial Mechanics, Immune Trafficking, and Aerosolized mRNA Delivery

This paper introduces a membrane-free alveoli-on-a-chip using biodegradable scaffolds that mimics interstitial mechanics, immune trafficking, and aerosolized mRNA delivery in human alveoli.

Rapid functional classification of cardiac genetic variants directly informs precision cardiology

This paper introduces REVi-SCOPE, a platform that rapidly characterizes cardiac variants' functional impact, enabling precision cardiology by analyzing VUSs in 10 days.

Coordinated Tuning of Ionizable Lipids and Formulation Redirects mRNA Vaccines Toward Lymphoid-Specific CD4+ T Cell Immunity

This study shows that modifying ionizable lipids and formulation parameters of mRNA vaccines can enhance CD4+ T cell immunity and improve vaccine efficacy.

Mesoscopic Fluorescence Imaging of Light-Triggered Chemotherapeutic Release in Cancer Spheroid Models

The paper evaluates a laparoscopic fluorescence imaging platform to quantify light-triggered drug release in cancer models, showing strong correlation with standard measurements and potential for guided treatment.

Adapting a two-photon scanning microscope for simultaneous single-photon imaging of an infrared dopamine sensor

The paper adapts a two-photon microscope to detect both visible and near-infrared fluorescence, enabling simultaneous dopamine and calcium imaging in the retina.

Synthetic Control of Implanted Engineered Liver Tissue Growth

This paper develops a method to grow engineered liver tissue in vivo by using synthetic biology to trigger on-demand expansion after implantation.

Machine Learning applied to MALDI-TOF data in a clinical setting: a systematic review

This review evaluates ML applications for MALDI-TOF MS in clinical microbiology, identifying trends and challenges in bacterial identification, resistance prediction, and strain typing.

In silico analysis of the invasion mechanics and invasiveness of the plasmodium falciparum merozoite

This study uses computational models to analyze how erythrocyte deformability affects merozoite invasion and identifies mechanical markers for drug screening.

Task-Specific Computational Fluid Dynamics Evaluation of Multi-Outlet Extrusion Nozzles for Bioprinting

This paper evaluates multi-outlet nozzle designs for bioprinting using computational fluid dynamics to determine optimal geometries for different printing tasks.

Controlled linking of AAV capsids enables coordinated multi-vector delivery

This paper introduces a method to link AAV capsids for coordinated delivery of genetic cargo, improving efficiency and uniformity in gene delivery.

Capture, Confine, Characterize: High-Throughput Dielectrophoresis-Based Single-Cell Microfluidics Platform to Analyze Mammalian and Yeast Cells Using Raman Spectroscopy

The paper introduces a microfluidic platform that traps and analyzes single cells and droplets using dielectrophoresis and Raman spectroscopy, enabling high-throughput, non-destructive cellular analysis.

A generative AI framework for disease-specific lung microtissue bioengineering

This paper introduces a generative AI framework for designing and fabricating disease-specific lung microtissues using 3D imaging and bioprinting.

MRI-Based Blood Clot Phenotyping: An In Vitro Study

This study shows MRI can predict blood clot composition and contraction state using radiomic features, supporting its use for pre-interventional clot phenotyping.

Vitamin C-Induced Photo-Redox Threshold Enables High-Fidelity Volumetric Printing of Pristine Collagen

This paper introduces vitamin C as a redox regulator to enable high-fidelity volumetric printing of pristine collagen by establishing a tunable nonlinear polymerization threshold.

Biomimetic 3D mammary duct models of healthy and tumoral tissues engineered by a co-extrusion microfluidic based technology

The paper develops 3D mammary duct models of healthy and tumoral tissues using a microfluidic co-extrusion platform to better mimic breast tissue architecture and function.