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This study identifies a hydrophobic grease that enables X-ray diffraction data collection across a wide temperature range, from 100 K to 300 K, with minimal exposure time effects.

This study develops a coarse-grained model to simulate phosphorylated disordered proteins, showing that phosphorylation's effect on global dimensions is mainly due to additional charge.

This study identifies a novel binding pocket in the SCAP-INSIG complex involved in cholesterol recognition using molecular dynamics simulations and AlphaFold3.

This study investigates how electric stimulation affects layer-specific LFPs in monkey V1, finding that deeper layers show phase-dependent changes while superficial layers do not.

This study examines collagen levels in tonsils of patients with acute recurrent tonsillitis and obstructive sleep apnoea to better understand disease pathophysiology.

This paper shows that the C-terminal tail of EmrE prevents proton leak by acting as a secondary gate, which is unlocked by substrate binding.

The paper explores new nanopore sensors from the aerolysin family by analyzing structure and sensing capabilities of three family members, finding ETX can translocate ssDNA with higher sensitivity than aerolysin.

This study identifies SpeMreB1 as the most active MreB isoform in Spiroplasma, which manages SpeMreB5 polymerization to drive swimming motility.

This study investigates how different AFM tip geometries affect the mechanical properties of multi-cellular spheroids, revealing multiscale responses and the importance of probe selection.

This study explores CEST MRI at 7T to detect and quantify cryoprotectants in organ cryopreservation, showing formamide's sensitive concentration-dependent response.

This study presents three new crystal structures of STEP (PTPN5) revealing unexpected conformational features and ligand binding events that provide insights for structure-based drug design.

This study demonstrates that carbon nanotube porins and electric fields can modulate membrane potential in glioblastoma cells, altering cellular metabolism and the cell cycle.

The paper assesses a micro-sprayer assay for ribosome functional activity, finding increased GFP production due to mechanical agitation, with implications for time-resolved cryo-EM experiments.

The paper introduces a deep learning tool called Metric Ion Classification (MIC) to classify ions and waters in cryo-EM and x-ray crystallography structures, identifying mismodeled ions in the PDB.

This paper introduces a foam film vitrification method for cryo-EM that improves ice thickness control and particle orientation, simplifying specimen preparation.

This study uses multiscale modeling to show that microtubule plus-end tips bend outward into curved structures regardless of GTP hydrolysis state, challenging existing models linking curvature to nucleotide state.

The paper characterizes CryoRhodopsins from cold environments, revealing their dual functionality and structural adaptations to low temperatures.

The paper maps strain fields around root tips using synchrotron X-ray techniques and validates findings with finite element simulations.

This paper demonstrates the feasibility of cardiac diffusion kurtosis imaging (DKI) in humans using high gradient strength MRI, showing non-Gaussian water diffusion behavior and significant radial kurtosis differences.

This study predicts globular protein partitioning into condensates using hydration free energy, showing strong correlation with partition coefficients and highlighting limitations of the approach.