Discover, rate, and discuss biology preprints.

The paper introduces SOFFA, a method improving magnetic resonance spectra signal-to-noise ratio by 5.6-10.3 times across different experiments without increasing acquisition time.

The paper develops a mathematical model that integrates pressure and osmolarity gradients in systemic circulation, showing how cell properties influence transport and vice versa.

This study uses molecular dynamics and PCA to analyze coordinated movements in tyrosinase subdomains, showing mutations disrupt stability by disrupting helix coordination.

This study investigates how different fluorescent tags affect the phase separation ability of HP1α in vitro and shows that PEG-based crowding agents can alter phase separation behavior.

This paper designs a high-affinity nanobody against SARS-CoV-2 spike protein using CDR-grafting combined with molecular simulation and machine learning.

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

This study determines the cryo-EM structures of EAAT3 bound to different substrates, revealing how conformational changes and sodium binding influence substrate recognition and transport.

This study shows ratiometric signaling allows cells to integrate temporal receptor activity for accurate gradient sensing despite noise.

This study investigates how lenacapavir affects HIV-1 capsid structure and nuclear entry by combining simulations and live-cell imaging, showing that it causes hyperstabilization and structural defects leading to capsid failure.

The paper studies how actin dynamics and tension affect endothelial cell mechanics under pressure, showing strain-stiffening and actin-driven reorientation.

The paper models synaptic spine head morphology using graph grammars to simulate actin dynamics and their effects on membrane shape.

The paper shows that weak specific protein interactions in cellular compartments determine barnase stability, differing from in vitro and artificial crowding conditions.

This study develops a method to accurately measure the elastic modulus of extracellular vesicles, showing that surface adhesion and membrane fluctuations significantly affect the results.

This paper introduces an open-source 3D active stabilization system for fluorescence microscopy to maintain sample stability during long imaging sessions.

This paper presents the structure and thermodynamic analysis of the extended RNA recognition motif in hnRNPR-like proteins, revealing a conserved tryptophan cage motif critical for folding and stability.

This paper identifies a new mode of large-scale collective motion in epithelial cells, showing they behave as polar elastic solids with scale-free correlations and Goldstone modes, distinct from fluid-like dynamics.

This study uses a 3D active foam model to show how cell-cell adhesion and friction influence rigidity transitions in cell monolayers, with implications for tissue mechanics and cancer metastasis.

This study uses cryo-electron tomography to show that sialic acid binding causes influenza HA trimers to cluster and form triplets on virions.

The paper develops a mathematical model of mammalian outer hair cell hair bundles with three rows of stereocilia, showing it predicts mechanical creep and MET current adaptation in response to stimuli.

This study uses enhanced sampling to reveal how crossover points in PX/DNA structures enhance nuclease resistance by altering helix topology and reducing DNase I binding affinity.