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Aging Alters Hair Cell Physiological Properties in Mice with Late-Onset Age-Related Hearing Loss.

This study shows that hair cell function declines with age in mice before hearing loss is detectable, challenging the idea that stereocilia are the most fragile part of sensory cells in aging.

AKAP5 and Caveolin-1 organize opposing nanodomains that regulate smooth muscle contraction and blood pressure

The paper identifies AKAP5 and caveolin-1 as organizers of opposing nanodomains that regulate smooth muscle contraction and blood pressure through distinct signaling pathways.

Sweet interference: oral fermentation volatile confounders in exhaled breath revealed by minimal glucose exposure.

This study identifies oral microbiome-derived VOCs as confounders in breath analysis by showing glucose-induced changes in exhaled acetoin, acetic acid, and ethanol levels.

One organ, two engines: divergent mitochondrial phenotypes in anterior and posterior crab gills

This study compares mitochondrial function in anterior and posterior gills of shore crabs, finding distinct phenotypes linked to their specialized roles in respiration and osmoregulation.

The Energetic Cost of Building Human Skeletal Muscle

The paper calculates the energetic cost of building human skeletal muscle using a bottom-up model, finding a central estimate of 14570 kJ/kg (3481 kcal/kg) of metabolizable energy required.

Evaluation of a Novel Recombinant Human Protein Formula Compared to Donor Human Milk and Standard Formula in Neonatal Piglets

This study evaluates a novel infant formula with recombinant human milk proteins in neonatal piglets, finding it noninferior to donor human milk and standard formula in growth and intestinal health.

Glucose derived redox equivalents preserve PKA activity and glucagon secretion during hypoglycaemia

This study shows that glucose metabolism via the pentose phosphate pathway maintains PKA activity and glucagon secretion during hypoglycaemia by elevating cytosolic redox potential.

Axonopathy in Duchenne Muscular Dystrophy limits microdystrophin gene therapy efficacy

This study shows that axonopathy in DMD limits microdystrophin gene therapy efficacy by demonstrating that dystrophin is expressed in peripheral nerves and its absence causes nerve structural collapse and impaired nerve-muscle connectivity.

Lognormal Neural Point Process Models for Interpretable Heartbeat Dynamics

The paper applies a lognormal mixture neural temporal point process to model heartbeat dynamics, showing improved robustness to noise compared to an inverse Gaussian model.

Microbial metabolism of mannitol as a tracer for the non-invasive measurement of oral-cecal transit

This paper introduces a non-invasive method to measure oral-cecal transit time in mice by tracking microbial oxidation of 13C-mannitol to 13CO2 using spectroscopy and calorimetry.

Towards a Physiological Scaling Law: Model Quality vs. Cohort Size for Stochastic Sequence Data

The paper evaluates scaling laws for stochastic sequence data using distributional calibration metrics, showing that performance improves with cohort size beyond point accuracy saturation.

MS4A8B regulates Orai1-dependent Ca2+ influx to control motile cilia function in human nasal epithelial cells

This study identifies MS4A8B as a regulator of Orai1-dependent Ca2+ influx in human nasal epithelial cilia, linking it to ciliary function and mucociliary clearance.

Cardiac microtubules mediate transverse (t)-tubule growth and homeostasis

This study shows that cardiac microtubules regulate t-tubule formation and maintenance through BIN1-CLIP-170 and dynein mechanisms, impacting Ca handling and contractile function.

Distinct extracellular matrix states uncouple collagen accumulation from pathological fibrosis in Duchenne muscular dystrophy

The paper shows that collagen abundance alone does not define fibrosis in DMD, as distinct matrix states with different biological activities and mechanosignaling exist.

Antibody-mediated inhibition of ADAMTS-7 reduces experimental atherosclerosis

This study develops a monoclonal antibody against ADAMTS-7 that reduces atherosclerosis in mice without affecting lipid levels or causing toxicity.

Hydrogen sulfide-mediated vasodilation requires heme oxygenase-derived carbon monoxide

This study shows that hydrogen sulfide-induced vasodilation depends on heme oxygenase-2-derived carbon monoxide and TRPV4 channels in endothelial cells.

Acute exposure to cell-free mitochondrial DNA induces pregnancy-specific aortic endothelial dysfunction and organ-selective inflammation in rats

This study shows that acute exposure to cell-free mitochondrial DNA in pregnant rats causes aortic endothelial dysfunction and organ-specific inflammation, with partial TLR9 involvement.

Isl1+ Central Amygdala Neurons Coordinate Control of the Jaw and Stomach During Ingestion

This study identifies CeAIsl1+ neurons in the central amygdala that coordinate jaw and stomach functions during ingestion by modulating reflexes and gastric motility.

Obesity and sarcopenia affect the metabolite profiles of pet dogs

This study examines how obesity and sarcopenia alter metabolite profiles in dogs, finding increased inflammation and lipid metabolism disruptions in overweight dogs and modest metabolic effects in those with reduced muscle mass.

Maternal progesterone signaling establishes lifelong oral homeostasis

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.