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Wildlife trade drives animal-to-human pathogen transmission over 40 years

Legally traded wild mammals have higher odds (OR 2.72) of sharing pathogens with humans, and each 9 years in global trade adds roughly one human-shared pathogen.

Cross-species transmission of human hepatitis B virus to wild Neotropical primates

Sequenced HBV from wild Amazonian primates in a deforested, densely settled region matched human genotypes A and D, while pristine-forest monkeys were all negative, consistent with human-to-primate spillover.

DefensePredictor: A Machine Learning Model to Discover Novel Prokaryotic Immune Systems

DefensePredictor combines ESM2 protein language model embeddings with genomic context features in a gradient boosting classifier to identify prokaryotic anti-phage defense genes, validating 45 previously unknown Escherichia coli systems.

AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network

ROCKET refines AlphaFold2 predictions against crystallographic, cryo-EM and cryo-ET data by gradient descent on MSA cluster profiles, capturing loop flips and domain shifts without retraining.

A new phylogeny and phylogenetic classification for Solanaceae

A 1,474-species 10-marker phylogeny and a 110-taxon Angiosperms353 phylogenomic dataset support a rank-free PhyloCode classification defining 38 clades across Solanaceae, including 16 infrageneric clades in Solanum.

A breath of fresh air: comparative evaluation of passive versus active airborne eDNA sampling strategies

Passive 3D-printed Nutshell air eDNA samplers hung up to 96 hours at Rotterdam Zoo detected 76 vertebrate species, versus 50 and 25 for two active samplers.

Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes

Cell Painting in primary human hepatocytes exposed to 1,085 compounds detects bioactivity at lower concentrations than cytotoxicity assays and predicts cell-based, but not cell-free, ToxCast endpoints across feature extractors.

Integrating 730,947 exome sequences with clinical literature improves gene discovery

gnomAD v4 (730,947 exomes) brings LOFTEE-2 loss-of-function annotation (0.90 precision, strict mode), missense-aware constraint, and LLM-mined literature evidence combined with constraint to rank disease genes.

S-MiXcan: Inferring Cell-Type-Level Transcriptome-Wide Associations from Bulk Transcriptomics Using GWAS Summary Statistics

Cell-type-aware TWAS from bulk-trained expression models and GWAS summary statistics reproduces individual-level MiXcan results (r > 0.99) and finds 32 genome-wide significant breast cancer genes.

Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis

Imaging of mitochondria and lipid droplets (LDs) across mouse liver lobules shows fasting, not Western diet, expands mitochondria-LD contacts; PLIN5 phosphomutants tune contacts and lipid storage.

Whole-genome prediction of bacterial pathogenic capacity on novel bacteria using protein language models, with PathogenFinder2

A ProtT5-embedding, ConvNext-plus-attention ensemble predicts human pathogenic capacity from whole bacterial genomes, outperforming prior predictors on species absent from training and flagging influential proteins.

PlantScience.ai: An LLM-Powered Virtual Scientist for Plant Science

PlantScience.ai couples an LLM-built, continuously updated plant science knowledge graph (4.0 million entities, 10.8 million edges) with graph-based retrieval for citation-traceable plant biology answers.

An activated wheat CCG10-NLR immune receptor forms an octameric resistosome

Activated wheat CCG10-NLR immune receptor WAI3 and Arabidopsis RPS2 assemble into octameric calcium-permeable resistosomes with an inverted coiled-coil domain topology associated with lacking the conserved EDVID motif.

Divalent siRNA for prion disease

Divalent siRNA 2439-s4 lowers human PrP to 17% residual in transgenic mouse brain after one dose, and a separate mouse Prnp-targeting siRNA extends survival in prion-infected mice.

Subjective and psychophysiological response to pictures of ancestral and modern threats: not all evolutionary threats are alike

Skin resistance responses in 119 non-phobic adults were most frequent and largest for height images; venomous snakes and firearms did not differ in response probability.

Earliest Evidence of Elephant Butchery at Olduvai Gorge (Tanzania) Reveals the Evolutionary Impact of Early Human Megafaunal Exploitation

Excavation of the 1.78 Ma Emiliano Aguirre Korongo site and landscape surveys across Olduvai Gorge Bed II reveal systematic early Pleistocene hominin butchery and percussive bone breakage of elephants.

Large language models possess some ecologicalknowledge, but how much?

Benchmarking GPT-4o and Gemini 1.5 Pro across five closed-book ecological tasks shows solid coarse species presence and trait recall but poor fine-scale range mapping and threat classification.

An integrative taxonomic approach reveals unexplored diversity in Croatian planarians

Degenerate COI primers combined with histology, karyology and transcriptomics raise the known Croatian freshwater planarian species from eight to sixteen and describe Dendrocoelum pigmentatum sp. nov.

A deep-time landscape of plant cis-regulatory sequence evolution

Conservatory, an orthogroup-centric conserved noncoding sequence finder, catalogs 2.3 million unique CNSs across 314 plant genomes and reveals regulatory elements older than angiosperms and seed plants.

Genetically proxied inhibition of angiotensinogen synthesis is associated with lower cardiovascular risk

AGT variants mimicking hepatic angiotensinogen synthesis inhibition are linked, via drug-target Mendelian randomization, to lower coronary artery disease, stroke and heart failure risk and higher potassium.