A. Chen

A robust and versatile nanobody platform for drug delivery

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

Energy Shortage in Human and Mouse Models of SLC4A11-associated Corneal Endothelial Dystrophies

This study identifies metabolic dysfunction and mitochondrial impairment in SLC4A11-deficient corneal endothelial cells as the cause of dystrophy.

De novo design of ACE2 protein decoys to neutralize SARS-CoV-2

The paper designs de novo ACE2 protein decoys to neutralize SARS-CoV-2 by blocking viral entry, showing high affinity and potent in vitro inhibition.

Lipidome profiles of plasma microvesicles differ in experimental cerebral malaria, compared to malaria without neurological complications

The paper compares lipidome profiles of plasma microvesicles in experimental cerebral malaria and non-CM malaria, finding distinct lipid changes associated with CM.

Effects of regulatory network organization and environment on PmrD connector activity and polymyxin resistance in Klebsiella pneumoniae and Escherichia coli

This study investigates how regulatory network organization and environmental factors influence PmrD connector activity and polymyxin resistance in K. pneumoniae and E. coli.

Epistatic interactions between PHOTOPERIOD-1, CONSTANS 1 and CONSTANS 2 modulate the photoperiodic response in wheat

The paper shows that PPD1 has a stronger effect on wheat heading time than CO1 and CO2, and that these genes can function independently in photoperiodic responses.

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

This study identifies redundant cytokine signals, particularly IL-6, IL-21, and IL-23, that drive Th17 cell differentiation in mesenteric lymph nodes induced by segmented filamentous bacteria.

Remote-controlled insect navigation using plasmonic nanotattoos

This paper develops a non-invasive method to remote control insects using plasmonic nanotattoos that preserve tissue integrity and enable environmental sensing.

Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge

The paper evaluates digital biomarkers from wearable data to predict Parkinson's disease status and symptom severity using a crowdsourced challenge.

Broadly Conserved Roles of TMEM-131 Family Proteins in Intracellular Collagen Assembly and Secretory Cargo Trafficking

This study identifies TMEM-131 family proteins as conserved regulators of collagen assembly and secretion across species, showing their role in ER stress and collagen production.

Evaluation of High-Pressure Processing in Inactivation of the Hepatitis E Virus

This study evaluates high-pressure processing (HPP) in inactivating HEV-3 in media and pork pate, finding matrix-dependent efficacy.

Estimation of immune cell content in tumor using single-cell RNA-seq reference data

The paper develops a method to estimate immune cell content in tumors using scRNA-seq reference data, showing improved performance over existing methods in distinguishing immune subtypes.

Gating Mechanism of β-Ketoacyl-ACP Synthases

The paper investigates the gating mechanism in β-ketoacyl-ACP synthases using structural and dynamic analyses to reveal how substrate discrimination occurs during catalytic reactions.

Characterization of Rhodopseudomonas palustris population dynamics on tobacco phyllosphere and induction of plant resistance to Tobacco mosaic virus i

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation

This study develops six monoclonal antibodies to deplete immune cells in mice, enabling MHC-mismatched HSC transplants without chemotherapy or radiation, leading to immune tolerance.

Access COI barcode efficiently using high throughput Single End 400 bp sequencing

The paper introduces a high-throughput sequencing approach to efficiently generate full-length COI barcodes using SE400 data, achieving high accuracy in species identification.

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

This study shows that co-housing PCOS mice with healthy mice improves reproductive and metabolic PCOS symptoms, suggesting gut microbiome manipulation could be a treatment.

Identity domains in complex behavior: Toward a biology of personality

The paper introduces a mathematical framework to study individual differences in behavior and gene expression in mice, validated using high-throughput behavioral data.

Comprehensive analysis of lung cancer pathology images to discover tumor shape features that predict survival outcome

This study uses a deep CNN to analyze lung cancer pathology images, identifies tumor shape features linked to survival, and develops a prognostic model validated in an independent cohort.