C. Chang

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

This study shows NDP52 allosterically activates ULK1 complex membrane recruitment via FIP200 coiled-coil conformational changes, essential for xenophagy and mitophagy.

Loss of mutant TP53 does not impair the sustained proliferation, survival ormetastasis of diverse cancer cells

This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.

Genetic interactions shaping evolutionary trajectories in an RNA virus population

The paper analyzes mutation dynamics in a poliovirus population using high-resolution sequencing to identify interactions like clonal interference and hitchhiking that shape evolutionary trajectories.

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

The paper reconstitutes autophagy-related reactions and shows that a positive feedback loop between PI3KC3-C1 and WIPI2 accelerates LC3 lipidation.

Obesity Potentiates TH2 Immunopathology via Dysregulation of PPAR

This study shows obesity increases TH2 immunopathology by disrupting PPARγ in T cells, and TZDs can protect against this effect in obese mice.

Large-scale Analysis of 2,152 dataset reveals key features of B cell biology and the antibody repertoire

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

Genomic acquisitions in emerging populations of Xanthomonas vasicola pv. vasculorum infecting corn in the U.S. and Argentina

The paper identifies gene acquisitions in Xanthomonas vasicola pv. vasculorum genomes from the U.S. and Argentina, linking them to increased virulence through horizontal gene transfer, including a prophage from X. vasicola pv. holcicola.

Dietary intake regulates the circulating inflammatory monocyte pool

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

Pathogenic potential of Hic1 expressing cardiac stromal progenitors

This study identifies cardiac stromal progenitors as multipotent cells that contribute to fibrosis and arrhythmogenic cardiomyopathy under different pathological conditions.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

Morphological plant modeling: Unleashing geometric and topological potential within the plant sciences

This paper discusses the importance of mathematical modeling in plant morphology and outlines challenges and opportunities for integrating geometric and topological approaches in plant science research and education.

Tuning the course of evolution on the biophysical fitness landscape of an RNA virus

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.