D. Liu

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

This study identifies TNY1, a cytosolic RNA-binding protein, as a key regulator of cell size homeostasis in Chlamydomonas through subscaling, which controls division number and daughter cell size.

This study identifies SIK3 as a key mediator of β-adrenergic signaling in adipose thermogenesis, showing that its inhibition promotes browning and thermogenic gene expression.

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

This study examines how HE4 contributes to hyperoxia-induced alveolar damage in rats by activating ERK and p65, modulating MMP9 and TIMP1 pathways, and promoting fibrosis.

The paper identifies novel non-synonymous variants associated with extreme vascular outcomes in Williams-Beuren syndrome through whole-genome sequencing and pathway analysis.

This paper identifies a new mechanism by which NPRC inhibits NP signaling by forming heterodimers with NPRA or NPRB, preventing cGMP production.

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

This study shows that a BR-binding-deficient BRI1 mutant is internalized similarly to wild-type BRI1, suggesting parallel endocytic routes and non-canonical functions.

The paper constructs a promoter-GFP fusion reporter library to study the systemic expression patterns of 41 c-di-GMP metabolism-related genes in Pseudomonas aeruginosa under various growth conditions.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.

This study shows that GLP-1R agonist liraglutide induces PKA-mediated phosphorylation of Raptor at Ser791, which contributes to its weight loss effect.

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

This study evaluates the effects of different durations of enriched environment intervention on intestinal mucosal barrier function and brain-gut axis in rats with colorectal cancer, finding that 8 weeks of intervention was most beneficial for the intestinal barrier.

The paper identifies plasma proteomic biomarkers that predict non-response to PD1 blockade in melanoma patients and links them to tumor microenvironment biology.

This study develops and evaluates USC-373, a phosphonate prodrug of HPMPC, showing efficacy against VZV in cell cultures and mouse models with improved potency and bioavailability.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

This study investigates the role of individual hydrogen bonds in facilitating the self-adherence of the TDP-43 low complexity domain.

This study shows that progestin receptors regulate coagulation factors during ovulation in zebrafish, linking blood clotting to the ovulation process.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

The paper isolates and characterizes two novel photosystem I supercomplexes from cyanobacteria, revealing the structure of the PSI octamer at near-atomic resolution.

This study profiles flavone accumulation in seven Scutellaria species, revealing organ-specific patterns and identifying a rare 4-hydroxyflavone isomer in some species.

This study shows that MyD88, not TRIF, is required for DC activation and alloantibody response to stored syngeneic RBCs in mice.