G. Wang

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

This study identifies 24 putative ORI events in crustacean mitochondrial genomes, showing that inversion events and gene strand switches can create mutational biases affecting phylogenetic and evolutionary analyses.

This study classifies and analyzes the expression of heat shock proteins in wheat infected with powdery mildew and stripe rust, revealing structural diversity and differential expression patterns.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This paper presents a dataset of speed-resolved blood perfusion and oxygen saturation in human skin under thermal stimulation and control conditions.

The paper shows that commensal microbes up-regulate host transferrin to suppress TLR signaling and promote immune tolerance in the gut.

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study reports cryo-EM structures of SIgA complexes, revealing their assembly mechanism and interaction with SpsA, a pneumococcal adhesin.

The paper develops a discrete dynamic model for human epidemics and identifies key parameters influencing total cumulative cases through sensitivity analysis.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

This study examines bacterial community diversity and structure across different rhizocompartments of desert leguminous plants, revealing significant niche-driven variability and core microbiomes.

This study identifies cinnamoyl-CoA reductases (CCR) as benzaldehyde synthases in cucumber, showing their specific expression and enzymatic activity in roots and flowers.

This study shows RTR-1, a compound from Rhodomyrtus tomentosa, inhibits gastric cancer cell proliferation by inducing ER stress and blocking the STAT3 pathway, while causing G2/M phase cell cycle arrest.

This study shows that PPAR-α activation increases herpesvirus replication, suppresses type I interferon, and inhibits STING signaling through ROS.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

The paper uses MD simulations to study ligand transport by P-gp and shows lipids also play a role in this process.

The paper identifies a moth pheromone receptor not belonging to the known subfamily, suggesting two independent origins of type I pheromone tuning in Lepidoptera.

The paper identifies chromatin state transitions in rice shoots under phosphate starvation that correlate with differentially expressed genes involved in cell wall remodeling.

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

This paper introduces a Tmem119-tdTomato reporter mouse model to specifically study microglia in the CNS, showing tdTomato+ cells are microglia-specific and detectable in health and disease.

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.

The paper compares transcriptome profiles of maize CSSLs I178 and X178 under accelerated ageing to identify genes and alternative splicing events associated with seed longevity.

The paper shows that host sex and genotype influence the gut microbiome response to helminth infection in fish.

This study identifies HN1 as a predictive and pharmacodynamic biomarker of metformin response in endometrioid endometrial cancer, showing it is elevated in responders and decreases after treatment.