H. Liu

This paper introduces a multi-dimensional separation method for glycosaminoglycan oligosaccharides that enables structural and functional analysis without desalting.

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

This paper develops an intravital imaging platform to study P. falciparum sporozoite motility in human skin xenografts and tests interventions against malaria sporozoites.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

This study shows that adding extracellular polymer substances (EPS) increases methane production in anaerobic digestion by enhancing microbial communities and electron transfer, without affecting sludge properties.

This study identifies Cdk1 phosphorylation as essential for forming the Ska-Ndc80 macro-complex, crucial for chromosome segregation.

The paper identifies a novel PSII subcomplex lacking reaction center proteins, suggesting a protective mechanism for PSII repair in cyanobacteria.

The paper compares 3654 chloroplast genomes to uncover evolutionary patterns in green plants, identifying gene clusters and IR expansions.

This paper introduces faster deconvolution and multiview fusion methods, achieving speedups of 10 to several thousand-fold over previous approaches.

WRI1 regulates genes encoding fatty acid synthesis and BADCs, which inhibit FA synthesis, creating a coordinated lipid homeostasis mechanism.

This paper evaluates the combination of artesunate and tetramethylpyrazine for treating experimental cerebral malaria, finding improved survival and neurological protection through proteomic analysis.

This paper engineers an acetyl-CoA metabolic shortcut in Yarrowia lipolytica to efficiently produce triacetic acid lactone from acetic acid, achieving a 8.5-fold increase in titer and 31.9% of theoretical yield.

This study shows calcineurin and Hog1 coordinate to control the cell cycle during stress by modulating transcription factors at multiple regulatory nodes.

This study identifies aroma-active compounds in three delicious apple juice cultivars using GC-MS, GC-O, and OAV, finding key contributors to the juice's aroma.

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

This study examines the energetics and stability of fish schooling using simulations, finding that energy expenditure and stability influence swimming patterns and synchronization.

This study systematically measures mutant phenotypes for genes in Bacteroides thetaiotaomicron to uncover gene functions and improve understanding of gut microbiota physiology.

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

The paper describes a modified TCA/acetone precipitation method for plant protein extraction that is faster and reduces protein degradation compared to traditional methods.

This study examines how biogas slurry affects soil nutrients and economic traits of Camellia oleifera fruits, finding that higher application rates improve soil fertility and fruit yield.

The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.

The paper identifies toxic inorganic ions that inhibit sensitive microorganisms and favor Rhodanobacter in a metal-contaminated aquifer.