H. Yang

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

The paper shows TRPV4 activates TMEM16F in trophoblasts, promoting cell fusion, and identifies this as a mechanism for syncytialization and disease-related fusion.

This paper investigates the concordance between two methods for detecting positive selection and finds that they often disagree, suggesting negative selection variation may mislead positive selection inferences.

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

This study improves watermelon transformation efficiency using AtGRF5 and Agrobacterium GV3101, achieving 25% efficiency and enabling CRISPR/Cas9-based knockout mutants.

This study identifies fluoxetine as a potential therapy for glioblastoma by inhibiting SMPD1 and enhancing temozolomide efficacy, with real-world evidence suggesting improved survival.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study identifies ADAR2 downregulation in t(8;21) AML and shows its role in suppressing leukemogenesis through RNA editing.

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

This study identifies a non-bactericidal cathelicidin, PopuCATH, that prevents bacterial infection by enhancing phagocyte influx and reducing inflammation without direct antimicrobial activity.

This study analyzes the reassortment network of Influenza A Virus using genome-wide data to identify reassortment events and their evolutionary implications.

This study shows that morphine exposure during adolescence affects c-Fos expression differently based on age, sex, and brain region.

This study demonstrates retron editing enables efficient precise genome editing in human cells without exogenous donor DNA, achieving up to 10% editing rates at endogenous loci.

This study identifies CD49a-expressing polyfunctional CD8 memory subsets in lung tissue that persist after influenza infection and exhibit diverse effector functions.

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

The paper analyzes metagenomic and metatranscriptomic data to understand factors driving vaginal microbiota composition and function, finding that transcriptional activity varies with community context.

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

This study identifies gene losses in subterranean rodents, showing their potential role in hypoxia tolerance and other adaptations.

This paper introduces a quantitative framework to describe integrated watershed ecosystems by analyzing flow networks and holistic properties across geomorphic, hydrological, ecological, and socio-economic dimensions.

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

This paper develops a neural network energy function for protein physics using unsupervised learning on 3D local structures, showing it can recognize patterns in protein structures.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper uses cryo-electron microscopy to visualize mitoribosome biogenesis, showing how GTPBP7 and NSUN4/MTERF4 regulate PTC formation and mitochondrial function.

This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.

This study models the future distribution of Rift Valley fever in East Africa under climate change scenarios using MaxEnt, identifying key environmental factors and predicting expanded disease spread.