H. Yang

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

This study shows that loss of maternal linker histone H1 in Arabidopsis facilitates DME-mediated demethylation in heterochromatin but has limited effects on endosperm gene transcription and imprinting.

This study identifies exodermal suberization as critical for drought tolerance in tomato, contrasting with Arabidopsis endodermis, and highlights the role of MYB92 and ASFT in this process.

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

This study identifies the mechanism by which Kingella kingae galactan is anchored to the bacterial surface via an interaction with an atypical lipopolysaccharide O-antigen.

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

This study shows that fibroblasts from pluripotent cells with single-allele knockouts in two pluripotency genes have DNA methylation issues and reduced pluripotency induction ability.

This study analyzes the adaptive immune landscape of T-cell mediated rejection in human kidney allografts using RNA sequencing and identifies key molecular features associated with rejection.

The paper models how adversarial interspecies relationships can enhance gene drive suppression in spatially structured populations, showing both benefits and risks for population elimination.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

The paper constructs a spatio-molecular lipid atlas of the human kidney using multimodal imaging and machine learning, revealing lipid profile variations related to sex and BMI.

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.

The paper shows that phase-separated TRB proteins aggregate with PRC2 to enhance Polycomb silencing in plants.

This study shows that m6A RNA methylation reduces gene expression variability and impairs reproductive thermotolerance in Arabidopsis under heat stress.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study analyzes neoantigen burden in breast cancer patients using whole-exome and RNA sequencing, finding high patient-specificity and correlation with somatic mutations.

This study uses scRNA-seq to identify metabolic reprogramming in human colonic immune cells across locations and ulcerative colitis states, linking metabolism to immune function and treatment resistance.

The paper identifies sustained epigenomic changes in hematopoietic stem and progenitor cells after COVID-19, which influence innate immune cell function and inflammation.

This study determines the 3D structure of HIV-2 immature Gag lattice using cryo-EM and identifies structural features critical for particle release and infectivity.

This study identifies amino acid residues in HIV-2 capsid protein critical for virus particle assembly by analyzing mutagenesis effects on assembly efficiency and morphology.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.