J. Liu

The paper sequences 242 Ae. tauschii accessions to study genetic diversity in the bread wheat D-subgenome, identifies disease resistance genes, and demonstrates their functional transfer into wheat.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

The paper evaluates the neutralization effect of BNT162b2 vaccine-elicited sera against SARS-CoV-2 variants with specific spike mutations.

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

The paper identifies LLP3 and LLP1 as key proteins in SAR signaling, with LLP3 promoting local signal generation and LLP1 facilitating systemic propagation, thereby disrupting SA-JA antagonism.

This paper develops a trans-complementation system to produce single-round infectious SARS-CoV-2 at BSL-2 labs, enabling safe high-throughput testing without full viral replication.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

This study investigates EEEV pathogenesis in cynomolgus macaques following aerosol challenge, finding that the virus replicates in the olfactory bulb and spreads via axonal transport, causing neuronal dysfunction rather than death.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

This study examines sex differences in hip adduction during running, finding females have greater peak hip adduction in both late swing and stance phases, with late swing adduction predicting stance phase adduction.

This paper introduces a precision-targeted metabolomics method capable of analyzing diverse biological matrices and identifies differential metabolomes in rats with CCl4-induced hepatitis.

A Fc-modified human antibody prevents SARS-CoV-2 viral infection via nasal administration.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This paper describes a method to generate virus-specific T cells from convalescent patients using artificial antigen presenting cells and rapid expansion, showing their potential as an adoptive cell therapy for COVID-19 and other viral infections.

This study shows that the Toll pathway effector BaraA protects Drosophila from toxins of Gram-positive bacteria and fungi without directly attacking the pathogens.

This paper develops a 3D reconstruction method using ATUM-SEM and deep learning to analyze hepatic organelle interactions and their morphology.

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

This study shows that docosahexaenoic acid (DHA) enhances the anti-cancer effects of carboplatin in ovarian cancer models, reducing tumor growth and improving survival.

This study uses cryo-electron tomography to compare 3D subcellular structures of wild-type and mutagenic Chlorella pyrenoidosa strains, revealing structural changes linked to increased growth rates.

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

This study evaluates deep learning denoising methods for improving particle tracking accuracy in noisy microscopy images, finding supervised learning generally outperforms unsupervised approaches.

The paper identifies a higher proportion of conserved enhancers during the phylotypic period of Drosophila embryogenesis and detects positive selection on enhancers at early and late stages.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.