J. Wu

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.

This study identifies GadR, a novel RofA-family transcriptional regulator in L. monocytogenes, which controls acid resistance by regulating the gadT2D2 operon and is linked to strain-specific survival differences in acidic environments.

This paper uses VR and eye-tracking to measure exposure, reception, and retention of messages in realistic environments, showing that attention manipulation affects gaze and memory.

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

This study develops a method to purify human FAM210A, a mitochondrial transmembrane protein, using E. coli and validates its interaction with EF-Tu.

This study identifies FAM210A as a regulator of mitochondrial translation and cardiac mitochondrial homeostasis, showing its deficiency leads to heart failure and its overexpression rescues cardiac function in ischemic heart disease.

The paper identifies an immunosuppressive class of glioblastoma (IDC) with high anti-inflammatory cytokine expression and poor prognosis, suggesting resistance to immune checkpoint blockade therapy.

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

The paper discovers new anammox bacteria in aquifers, expands taxonomic diversity, and highlights their role in nitrogen cycling.

This study identifies a farnesyl-dependent structural role for CENP-E in fibrous corona expansion during mitosis, independent of its motor activity.

This study identifies RLCK-VII subfamily members as essential for ROS production and signaling downstream of the Cf-4 resistance protein in N. benthamiana.

The paper identifies a 1.5 Mb viral region in Rhizophagus irregularis, suggesting recent infection by a dsDNA virus.

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

The paper investigates reticulate evolution in the genus Stranvaesia using phylogenomic data, revealing how hybridization and allopolyploidy influence taxonomic classification and leading to the description of a new genus.

The paper identifies DFD adaptors as energy reservoirs through supersaturation, showing their role in innate immune signaling and cell fate decisions.

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

This study identifies Zbtb46 as a regulator that coordinates angiogenesis and immunity in tumors, with its downregulation promoting a pro-tumor microenvironment and its restoration improving tumor outcomes.

This study shows that balanced nitrogen-iron nutrition increases tiller number, yield, and nitrogen use efficiency in rice and wheat through the NIN-like protein 4 mechanism.

This study identifies the OsNLP3/4-OsRFL module as a key regulator of nitrogen-promoted panicle architecture in rice, linking nutrient availability to developmental outcomes.

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.