J. Yang

This study uses GWAS to identify plant loci associated with rhizosphere microbiome composition in sorghum, showing heritable associations between plant genotypes and microbial taxa.

This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.

This paper assesses spatiotemporal changes in ecosystem service values in Xishuangbanna over two decades using remote sensing data and ecological economics theories.

The paper traces the evolutionary ages of cancer-driving sites using somatic mutations and finds that sites mutated in more cancer types are generally older.

The paper identifies a ternary complex, EMTosome, formed by Twist, Snail, and Sox9 that allosterically regulates Twist DNA binding during EMT.

The paper investigates the role of the nuclear lamina and microtubule regulators in C. elegans oocyte meiosis I spindle assembly, showing their contributions to microtubule organization and pole coalescence.

The paper identifies genetic factors underlying pelvic reduction in sticklebacks and shows how population structure limits local adaptation.

This paper shows that the Drosophila Torr transporter is essential for cuticle barrier function, similar to the human ABCA12 gene's role in skin lipid barriers, causing desiccation and ichthyosis-like phenotypes when dysfunctional.

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

This study examines the relationship between visual impairment, spectacle use, and academic performance in junior high school students in western China, finding that spectacle ownership is linked to better test performance.

This study identifies geldanamycin and its analog 17-DMAG as dual KDM/Hsp90 inhibitors effective against PAX3-FOXO1-driven rhabdomyosarcoma.

The paper systematically analyzes correlations between 221 physical examination indicators in healthy and disease states, identifies disease markers, and develops machine learning models to predict health status with high precision.

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

The paper introduces RFEX, a simple Random Forest explainer for non-ML experts, improving model and sample explainability with a tabular output and case study.

This study investigates chunking mechanisms in reading by analyzing lexical decision times and EEG responses to Chinese strings with varying chunk structures, finding that global chunks are processed before local chunks.

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

This study shows that blood collection tubes affect biomarker screening results in mass spectrometry, with coagulant tubes altering protein profiles and reducing biomarker detection.

The paper uses computational modeling to reveal a hydrophobic force-induced mechanism for pore formation in cholesterol-dependent cytolysins.

The paper introduces a semi-automated method for adenoma quantification in ApcMin mice using FeatureCounter, achieving comparable sensitivity and specificity to manual counting.

The paper identifies distinct ligand-directed plasma membrane signalsomes in Arabidopsis that drive biased signaling through compartmentation and different trafficking origins.

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

This study uses a microfluidic platform to show renal epithelial cells generate hydraulic pressure gradients, with PKD cells showing reversed fluid flow and higher stall pressure.

This study shows that miR-15a mimic, especially modified with 5-FU, reduces PDAC cell proliferation and tumor growth, suggesting its therapeutic potential and prognostic value.

The paper shows synthetic maize leaf images improve leaf counting accuracy when real-world data are limited, outperforming real data in some cases.

The paper validates a miniaturized permeability assay compatible with CRISPR-mediated genome-wide screens for thrombin-disruptive genes in endothelial cell junctions.

This study evaluates the methodological quality of animal studies using the SYRCLEs risk of bias tool, finding significant differences between Chinese and English studies.

The paper analyzes bacterial diversity succession in compost made from pig manure and wood chips using 16S rRNA gene analysis, showing shifts in microbial phyla over composting stages.

The paper identifies a key residue in a GPCR dimer using in-cell structure characterization and shows its impact on dimerization and signaling.

This study investigates the association between baseline alpha-2-macroglobulin levels and radiation-induced toxicities in thoracic radiotherapy patients, finding a link with esophagitis and developing predictive models for toxicity.