J. Yang

This study measures synaptic stiffness using a combined microscopy platform and finds it to be extremely high, correlated with spine size, and potentially regulated by neural circuit processes.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

This study investigates how posture affects intestinal absorption of glucose and fat by comparing plasma insulin curves in different positions in rats.

The paper examines how host plant species and nitrogen fertilization affect rhizosphere microbiomes in maize and soybean, identifying specific microbial taxa responding to these factors.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study performs a time-course transcriptome analysis of lettuce achenes to identify gene expression patterns and molecular mechanisms during achene development.

This study identifies SvFUL2, an A-class MADS-box transcription factor, as essential for inflorescence determinacy in Setaria viridis, showing that its disruption leads to indeterminate inflorescence and altered meristem behavior.

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.

This study identifies two CYP450 genes responsible for oxidizing friedelin to polpunonic acid in the celastrol biosynthesis pathway of Tripterygium wilfordii.

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.

This paper identifies a temperature-sensitive fer-ts mutant of FERONIA that affects root hair growth and hormone responses, with altered protein turnover and ROS accumulation at elevated temperatures.

The paper identifies PRMT5 as a synthetic lethal target with gemcitabine in pancreatic cancer using CRISPR screening in a PDX model.

This study identifies SDE2's role in stabilizing the TIMELESS-TIPIN complex to protect stalled replication forks and maintain genomic integrity.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

This study identifies RSH-1 as a lysosomal NADPH phosphatase that regulates ER proteostasis via mTOR signaling in C. elegans.

This paper evaluates how well thermodynamic folding and binding free energies predict the fitness of beta-lactamase mutants using experimental data and computational models.

This study examines the effects of dietary Citrus reticulata 'Chachi' products on the fecal microbiome of weaned piglets using multi-omics analyses, showing changes in microbial diversity, SCFAs, and proteomic profiles.

This study analyzes the evolutionary patterns of Sinocyclocheilus cavefish, identifying rate shifts, trait reversals, and novel traits in their morphological evolution.

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study introduces Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei, altering N-glycan processing and improving lignocellulose degradation while causing abnormal polarity and secretion phenotypes.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

This study identifies AfRip3 as a key modulator of necroptotic death in A. fumigatus, showing it is induced by Ca2+ and activates JNK and SMase pathways.

This paper develops a sensitive and reusable method for detecting Exo III activity using DNB nanoarrays and cPAS sequencing technology, showing a linear response in low concentration ranges.

The paper shows that APC/C and Cep152 interact at centrosomes during mitosis, with APC/C regulating Cep152 levels to control spindle assembly and chromosome segregation.

The paper identifies pGpp as a third alarmone in Bacillus and shows NahA converts (p)ppGpp to pGpp, altering alarmone composition and stress response.