J. Zhang

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

The paper uses glycopeptidomics to analyze host cell lines and identify specific glycopeptides associated with gastric MALT lymphoma, offering potential markers for early diagnosis.

The paper maps global tree diversity patterns and shows that both current and ancient climates influence tree species richness, functional, and phylogenetic diversity.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

BCM3D improves segmentation and classification of bacterial cells in 3D biofilms using deep learning and mathematical analysis.

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

The paper characterizes the structural features of Vicilin Buried Peptides (VBPs) using solution NMR spectroscopy, revealing a helix-loop-helix hairpin fold stabilized by disulfide bonds and inter-helix interactions.

The paper identifies a novel subset of quiescent alveolar type 2 cells in mice that expand after pneumonectomy and are enriched in PD-L1, with similar findings observed in human lungs.

The paper reports two cryo-EM structures of the SARS-CoV-2 spike protein, showing prefusion and postfusion conformations, and discusses their implications for viral entry and immune evasion.

The paper identifies two metabolic subclasses in pancreatic cancer cells and shows asparagine's role in supporting proliferation under mitochondrial stress, suggesting a new therapeutic strategy.

This study identifies 5mC regulators as prognostic markers in glioma using multi-omics analysis and develops a risk model to predict patient outcomes.

The paper introduces an iSUF platform to enrich and purify tumor-derived extracellular vesicles from biofluids, showing high enrichment and biomarker expression in clinical samples.

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This study identifies 24 putative ORI events in crustacean mitochondrial genomes, showing that inversion events and gene strand switches can create mutational biases affecting phylogenetic and evolutionary analyses.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.

This study shows ALKBH7 regulates glyoxal metabolism, and its deficiency protects against necrosis and ischemia-reperfusion injury through hormetic signaling involving methylglyoxal stress.

This paper uses deep learning to estimate histological staining intensity from MRI signals, creating virtual histology maps of mouse brains with enhanced sensitivity and specificity.

This study investigates how Duox and TLR3 genes in Hermetia illucens larvae suppress zoonotic pathogens by modulating intestinal bacterial community homeostasis through immune signaling pathways.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

The paper identifies myomegalin's role in regulating the Hedgehog pathway by tethering PDE4D3 to the centrosome, showing its impact on medulloblastoma growth.

This study shows that promoters and transcription factors coevolve antagonistically in animals and mutually in plants, leading to different transcriptional network transitions.

This paper presents a microfluidic ELISA technology for rapid, quantitative, and sensitive detection of SARS-CoV-2 biomarkers in small sample volumes.

The paper investigates how β-alanine and L-carnosine affect pork quality by modulating glycolysis and AMPK activity in porcine muscle.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

This paper maps 3D vascular niches for myeloid differentiation in bone marrow, revealing distinct spatial organization of granulocyte and monocyte/dendritic cell progenitors.

This paper introduces a light-driven molecular motor system to apply forces to cellular receptors, demonstrating its ability to manipulate cell adhesion and activation.