J. Zhang

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.

The paper shows that spatially distinct cAMP oscillations, in-phase with Ca2+ and out-of-phase with PKA, regulate signaling in pancreatic β cells through nanodomain clustering of adenylyl cyclases and phosphodiesterases.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.

The paper introduces DDC, a method to correct blinking artifacts in SMLM by using true pairwise distance distributions, improving spatial reconstruction accuracy.

This study shows that mitochondrial ETC inhibitors suppress LPS-induced inflammation in BV2 microglia by reducing TREM1 and p-STAT3/STAT3 ratios.

This study identifies RAS mutations as drivers of proliferative CMML through a novel KMT2A-PLK1 axis, showing PLK1 inhibition can improve disease outcomes in patient-derived xenografts.

The paper identifies a pathway linking calcium influx to focal adhesion turnover during cell migration through the ORP3/IQSec1 complex and Arf5 activation.

This study examines testosterone level changes in female giant pandas during estrus and finds that testosterone peaks 4 days after estradiol peaks and is only correlated with estradiol after the estradiol peak.

This study integrates radiomic and genomic data from HNSCC patients to find associations between imaging features and genomic biomarkers, achieving moderate predictive accuracy for HPV and TP53 mutation status.

This paper introduces Cryo-OrbiSIMS for 3D molecular imaging of bacterial biofilms, revealing the spatial distribution of quorum sensing molecules and membrane components in Pseudomonas aeruginosa.

This study combines mechanistic and machine learning models to optimize tryptophan metabolism in yeast, achieving a 106% increase in tryptophan accumulation through predictive engineering.

This study uses whole exome sequencing to track cervical cancer mutations during chemoradiation, finding that CDK4/CDK6/cyclin D1-related mutations persist or increase, suggesting radiation resistance.

The paper identifies genetic variants associated with invasion success in Drosophila suzukii using a new statistical method to correct for population structure.

This study develops an anti-somatostatin receptor 2 antibody-drug conjugate (ADC) that effectively targets and kills neuroendocrine tumors with minimal toxicity.

This study identifies genomic criteria to distinguish species from populations using Z-linked genes in butterflies and applies them to humans, finding that all modern humans are one species.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

This study shows gut bacteria enhance dsRNA-induced mortality in leaf beetles by accelerating dsRNA degradation and causing microbiota dysbiosis.

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This study shows that rabies virus glycoprotein suppresses gastric cancer migration by inhibiting the 7-nAChR-MEK/ERK-EMT pathway.

The paper identifies a mechanism by which extracellular domain EGFR mutations in glioblastoma are activated through covalent dimerization, rendering ATP-site inhibitors ineffective and paradoxically promoting proliferation.

This study shows that longer double-stranded RNAs accumulate more in plastids, leading to stronger RNAi effects against Colorado potato beetle larvae.

This paper identifies dimethylfasudil as a synthetic lethal compound for MYC-overexpressing cells through a high-content screen, showing its efficacy in rodent and human cell lines.

This study compares protein metabolism and regeneration in diaphragm and gastrocnemius muscles of hibernating and summer-active Daurian ground squirrels, finding distinct regulatory patterns contributing to hypertrophy and atrophy.

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

The paper shows EGF induces sustained plasma membrane ERK activity regulated by Rap1, distinct from transient cytoplasmic and nuclear ERK activity, highlighting spatial-temporal regulation in signaling specificity.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.