L. Huang

This study estimates the de novo mutation rate in pigs using whole-genome sequencing of a three-generation pedigree and revises the evolutionary timeline of pigs, including divergence events and domestication history.

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

This study shows that the cationic peptide L-K6 enhances doxorubicin's effectiveness in drug-resistant cancer cells by inhibiting P-glycoprotein function and expression.

This paper identifies rtcisE2F as a circRNA that regulates liver TIC self-renewal and metastasis by modulating E2F6 and E2F3 mRNA stability through m6A reader interactions.

This study uses lattice lightsheet microscopy to show that PI3K activity is critical for sealing ruffles into macropinosomes, but not for regulating their morphology.

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.

This study identifies how Listeria monocytogenes uses InlB to protect infected monocytes from CD8+ T-cell mediated death, facilitating neuroinvasion and persistence.

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.

This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.

The paper identifies circulating anti-tumor CD8 T cells using single-cell RNA sequencing and TCR sequencing, and develops marker panels for their detection in mice and melanoma patients.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

This study demonstrates that Fe/S-oxidizing bacteria accelerate mineral weathering and heavy metal encapsulation in sulfidic tailings, forming precursor mineral gels for hardpan formation.

This study shows Arabidopsis myosin XIK interacts with the exocyst complex to facilitate vesicle tethering during exocytosis, revealing a role in secretory processes in plants.

This study shows PRMT5 promotes cancer metastasis by enhancing EGFR transcription and modulating AKT1 activation through methylation, leading to EMT and tumor cell invasion.

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

The paper introduces a method to improve pathogen detection in metagenomic data by correcting abundance estimates using species-specific genomic regions, enhancing sensitivity and specificity for low-abundance pathogens.

This meta-analysis compares first-generation EGFR-TKI plus chemotherapy to EGFR-TKI alone in advanced EGFR-mutated NSCLC, finding improved ORR, PFS, and OS with the combination, but increased toxicity.

Endosidin20 inhibits plant growth and synergizes with other cellulose synthesis inhibitors, showing potential as a spray herbicide.

Endosidin20 inhibits cellulose synthesis by targeting the catalytic site of CESA6, reducing cellulose synthase complex delivery to the plasma membrane.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This study shows anacardic acid reduces PE-induced cardiac hypertrophy by inhibiting JNK signaling and HAT-mediated histone acetylation in mice.