L. Huang

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study identifies DVG generation in SARS-CoV-2 and links it to IFN stimulation and persistent infection, showing higher DVG levels in symptomatic patients.

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

This study identifies Breg as a batokine that regulates adipose thermogenesis and glucose homeostasis, showing its role in energy metabolism and potential therapeutic applications.

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

This study shows that the Hippo tumor suppressor pathway is activated in growth-arrested melanocytes, preventing melanoma development, and its inactivation allows BRAF-driven melanoma formation.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

This study investigates how hyaluronic acid biosynthesis affects metabolic regulation of tumor invasion in breast cancer cells using integrated experimental and computational approaches.

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

A comprehensive mutational analysis of the catalytic domain of Arabidopsis CESA6 reveals distinct roles for conserved motifs in CSC vesicle trafficking, protein complex formation, or protein dynamics.

This study shows E. coli can use DNA as a nitrogen source for growth, outperforming Bifidobacterium bifidum, and ingests long DNA directly without altering its length.

The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

This paper assesses swimming fatigue in large yellow croakers by analyzing metabolites and constructs an endurance swimming model to inform aquaculture site selection.

The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

This paper uses AI-enabled multiscale computational microscopy to study SARS-CoV-2 Delta variant in respiratory aerosols, revealing atomic-level insights into airborne transmission.

This paper develops a selectable marker-free gene targeting system in soybean using Ochrobactrum haywardense-mediated delivery, achieving 3.4% targeted insertion and 90% mutation rate in T0 plants.

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

This paper identifies a small molecule agonist of Mtb adenylyl cyclase Rv1625c that inhibits cholesterol utilization and disrupts Mtb pathogenesis in mice.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.