L. Li

This study shows that the APOE ε4 allele causes earlier age-related decline in amyloid β clearance in the human cortex, supporting early intervention strategies for Alzheimer's disease.

The paper identifies promoter sequence determinants and structural basis of primer-dependent transcription initiation in E. coli using MASTER and biochemical studies.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

This study compares epigenomic and transcriptomic changes in murine monocytes under low-grade and acute inflammation induced by LPS, identifying pathway-specific responses and epigenetic regulation differences.

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

This study shows autophagy promotes photomorphogenesis in Arabidopsis seedlings under carbon limitation by enhancing lipid turnover and chloroplast development.

The paper examines how different groundcover treatments affect beetle abundance, diversity, and biomass in tea plantations, finding higher species richness and abundance in certain treatments.

The paper identifies a novel SARS-CoV-2-related bat virus, PrC31, with complex recombination events and partial genetic similarity to SARS-CoV-2.

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.

The paper investigates the metapopulation structure of marine bacteria associated with diatoms, finding that closely related bacterial populations are host-specific and show functional differentiation.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

The paper identifies novel root growth regulators in Arabidopsis root tips through analysis of auxin-triggered (phospho)proteome changes.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

This study shows that a novel adjuvant can enable same-day protection against a lethal influenza virus challenge through IgM neutralizing antibodies.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

The paper examines subgenomic RNA (sgRNA) expression and structural variations in symptomatic and asymptomatic SARS-CoV-2 infections to correlate with disease severity.

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

The paper identifies two small proteins, MHA1 and MHA1L, that modulate ACD6 activity in Arabidopsis thaliana, affecting growth and defense trade-offs through calcium influx regulation.

This study examines splenomegaly, histopathology, and splenocyte composition in mice infected with Plasmodium berghei K173, showing strain-specific differences in parasite control and splenic function.

The paper introduces a microchip called NOMA that enables sequential tracking of secretions from the same single cells with high retention efficiency.

The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.