L. Li

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This study shows that SETD2 deficiency in mice worsens colonic inflammation and tumorigenesis by increasing oxidative stress and impairing epithelial barrier function.

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

High copper availability represses SPL7, releasing its suppression on key ABA biosynthetic genes and leading to increased ABA accumulation that inhibits growth but enhances drought tolerance.

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

This study identifies genomic signatures of recent adaptation in Bombus terrestris bumblebees, revealing genetic diversity and adaptive processes related to environmental interactions.

This study identifies SIRT1's role in regulating sphingolipid metabolism and neural differentiation in mESCs via c-Myc and SMPDL3B, suggesting therapeutic potential for neurological diseases.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

This study reveals that animals use geometric principles to break multi-choice decisions into binary decisions during spatial navigation, supported by experiments with fruit flies, locusts, and zebrafish.

This study examines how microbial phylogenetic relatedness influences bacterial and fungal community succession patterns across a 54-year post-mining chronosequence.

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

This paper proposes a method to measure heart rate remotely using a surveillance camera, achieving 95.8% accuracy at 4.5 meters and 90% at 5.0 meters under varying light conditions.

This study analyzes one million SARS-CoV-2 genomes to identify human-adaptive mutations and develop a simulator to predict viral evolution under different models.

This paper identifies a mutation in ENPP1 that selectively inhibits cGAMP degradation, enabling study of extracellular cGAMP's role in antiviral immunity and disease.

Librator is a platform for sequence editing and design of influenza virus proteins, enabling efficient mutation and chimeric protein creation for vaccine development.

The paper identifies autophagic protein cargo in Arabidopsis by analyzing changes in protein abundance and degradation rates in autophagy mutants.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

The paper identifies CSA1 as a TIR-NBS-LRR protein required for autoimmune cell death in Arabidopsis when BAK1 and BIR3 are mutated, linking BAK1 to NLR proteins in immune responses.

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.