L. Yang

The paper screens 5440 compounds to identify chemical inhibitors effective against multiple coronaviruses, including SARS-CoV-2, finding several FDA-approved drugs with potential for repurposing.

The paper develops trophoblast and decidua organoids to study antiviral defenses at the maternal-fetal interface, showing differential innate immune responses and susceptibility to HCMV.

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

This study uses paratransgenesis to knock down miR275 in tsetse flies, showing it disrupts midgut physiology and trypanosome infection.

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

This study identifies the Pseudomonas aeruginosa Tat pathway's role in PQS-dependent quorum sensing and biofilm maturation by showing that disruption of the Rieske cytochrome bc1 subunit impairs virulence factor production and eDNA release.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

This study shows alantolactone has antifungal effects against Candida albicans by inhibiting adhesion, biofilm formation, and cell membrane permeability.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study shows that non-enzymatic acetylation of lysine residues in Rubisco activase reduces its stability and ATPase activity under varying light and heat stress conditions.

The paper identifies Treg cell perturbations in severe COVID-19 patients, showing increased FoxP3 levels and pro-inflammatory traits linked to disease severity.

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

This study examines seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in a cold temperate zone, finding that altitude has stronger effects than season on community structure and diversity.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

The paper examines cross-reactive serum and memory B cell responses to SARS-CoV-2 and endemic coronaviruses, finding weak serum cross-reactivity but stronger memory B cell cross-reactivity.

This study identifies a single amino acid mutation that determines the difference in neutralization ability of a cross-reactive antibody between SARS-CoV-2 and SARS-CoV.

This study shows methionine synthase (MTR) is crucial for cells to avoid folate trapping and assimilate 5-methyl-THF into other folate species, supporting one-carbon metabolism and tumor growth.

This study shows that the bacterial QS molecule DSF suppresses Arabidopsis innate immunity by altering sterol biosynthesis and disrupting FLS2 receptor dynamics.

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

The paper shows that selection maintains adaptive division-of-labor between tandem duplicates of ATP1A1 in frogs, countering gene conversion to confer toxin resistance.

This study identifies T cell apoptosis and migration as mechanisms of peripheral T cell lymphopenia in severe COVID-19 and links lymphopenia to subsequent T cell proliferation.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

The paper identifies a unique protein architecture in Actinobacteria's -ketoacid dehydrogenase complex, showing a reduced acetyltransferase subunit with implications for drug targets.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.