L. Zhang

This study identifies SRF3 as a receptor kinase that coordinates iron homeostasis and immune responses in plants by regulating callose synthase activity.

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

The paper develops activity-based probes to analyze KLK activome dynamics in prostate cancer, revealing KLK14's role in migration and secretion into the bone microenvironment.

The paper evaluates clustering methods for microbiome data, identifies scenarios where specific metrics underperform, and proposes a combined metric that improves performance across datasets.

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

The paper examines how non-structural carbohydrates (NSCs) and fine root traits vary across root branch orders in Fraxinus mandshurica seedlings under different drought and soil conditions.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study uses metabolomics to investigate how PDE inhibition affects cNMP signaling in tomato under non-stress and salinity conditions, revealing growth changes and metabolic reprogramming.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

The paper develops a urine peptidomics workflow to identify chemically defined dietary gluten peptides in celiac disease patients, revealing differences from controls.

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.

This study shows that a bacteriophage inhibits murine norovirus replication in RAW 264.7 cells through activation of innate immune responses and guanylate binding proteins.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

The paper identifies RLP32 as the Arabidopsis receptor for the bacterial pattern IF1, revealing its role in PTI and resistance to Pseudomonas syringae.

The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.

The paper compares metatranscriptomic responses of Arabidopsis to endophytic and pathogenic Fusarium strains, revealing transcriptional plasticity and differential gene regulation.

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This study examines genome-wide transcriptional responses of marine nematode Litoditis marina to hyposaline and hypersaline stresses, identifying conserved and specific gene expression patterns.

This study shows that stimulating soluble guanylate cyclase (sGC) with BAY41-8543 reduces skeletal and cardiac muscle dysfunction in mdx mice, suggesting sGC as a therapeutic target for Duchenne muscular dystrophy.

This study identifies EZH2's role in promoting breast cancer bone metastasis through the integrin β1-FAK pathway and TGFβ signaling.

This study shows that O-glycosylation near the furin cleavage site of SARS-CoV-2 spike protein reduces furin cleavage and is mediated by GALNT enzymes and a proline at position 681.

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

The paper identifies ATF3 as a key driver of chromatin accessibility remodeling during senescence, linking it to the regulation of senescence programs.