L. Zhang

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

This study identifies ten Shaker K+ channel genes in foxtail millet and analyzes their expression under abiotic stresses and ABA treatment, revealing distinct regulation patterns.

The paper identifies two enzymes, CslZ and LpmP, involved in apical glycan deposition in Streptomycetes by remodeling peptidoglycan.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.

The paper links diet-derived metabolites and mucus to fever after cytotoxic cancer treatment by showing how Akkermansia muciniphila affects colonic mucus and inflammation.

This study identifies metabolic markers and pathways in pancreatic tumor-associated macrophages using multi-omic analysis and in vitro models.

The paper shows CDK-2 stabilizes crossover intermediates and pro-crossover factors in C. elegans, proposing a model of recombination nodule formation through condensation and coarsening.

This study identifies intragranular restructuring events during secretory granule maturation that mediate cargo segregation and reveals genes and factors involved in these processes.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

This paper introduces EEG-AVE, a model that combines EEG signals with audio-visual data to improve cross-individual affective detection performance.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

The paper shows that increasing cell size remodels the proteome and promotes senescence, but polyploidization can prevent this by altering the DNA-to-ploidy ratio.

The paper investigates microbiota dynamics and assembly patterns in a large water diversion canal, finding deterministic processes shape bacterial communities while stochasticity dominates micro-eukaryotic communities.

The paper analyzes human fecal virome data to identify viral enterotypes, finding two distinct patterns associated with health and disease.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This paper introduces a photoredox-catalyzed method for C-terminal labeling of peptides, applicable to bulk and single-molecule proteomics, achieving over 50% labeling efficiency across proteomes.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

The paper shows that PLK-2 inactivates CHK-2 in C. elegans to promote crossover formation and meiotic progression after synapsis.

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

This study shows that IGF-1C and P24 together enhance osteogenic differentiation of BMSCs by activating p38 and JNK pathways.